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Item 3D Printing of Human Ossicle Models for the Biofabrication of Personalized Middle Ear Prostheses(MDPI, 2022-10-31) Dairaghi, Jacob; Rogozea, Dan; Cadle, Rachel; Bustamante, Joseph; Moldovan, Leni; Petrache, Horia I.; Moldovan, Nicanor I.; Physics, School of ScienceThe middle ear bones (‘ossicles’) may become severely damaged due to accidents or to diseases. In these situations, the most common current treatments include replacing them with cadaver-derived ossicles, using a metal (usually titanium) prosthesis, or introducing bridges made of biocompatible ceramics. Neither of these solutions is ideal, due to the difficulty in finding or producing shape-matching replacements. However, the advent of additive manufacturing applications to biomedical problems has created the possibility of 3D-printing anatomically correct, shape- and size-personalized ossicle prostheses. To demonstrate this concept, we generated and printed several models of ossicles, as solid, porous, or soft material structures. These models were first printed with a plottable calcium phosphate/hydroxyapatite paste by extrusion on a solid support or embedded in a Carbopol hydrogel bath, followed by temperature-induced hardening. We then also printed an ossicle model with this ceramic in a porous format, followed by loading and crosslinking an alginate hydrogel within the pores, which was validated by microCT imaging. Finally, ossicle models were printed using alginate as well as a cell-containing nanocellulose-based bioink, within the supporting hydrogel bath. In selected cases, the devised workflow and the printouts were tested for repeatability. In conclusion, we demonstrate that moving beyond simplistic geometric bridges to anatomically realistic constructs is possible by 3D printing with various biocompatible materials and hydrogels, thus opening the way towards the in vitro generation of personalized middle ear prostheses for implantation.Item A High Sensitivity Custom-Built Vibrating Sample Magnetometer(MDPI, 2022-08) Phillips, Jared Paul; Yazdani, Saeed; Highland, Wyatt; Cheng, Ruihua; Physics, School of ScienceThis work details the construction and optimization of a fully automated, custom-built, remote controlled vibrating sample magnetometer for use in spintronics related research and teaching. Following calibration by a standard 6 mm diameter Ni disc sample with known magnetic moment, hysteresis measurements of Nd-Fe-B thin films acquired by this built vibrating sample magnetometer were compared to the data taken using a commercial superconducting quantum interference device and showed very similar results. In plane and out of plane magnetic hysteresis data acquired for 25 nm Fe thin films are also presented. The developed vibrating sample magnetometer is able to achieve a sensitivity approaching 1 × 10−5 emu. Further alterations to the design that may improve beyond this limit are also discussed.Item Absolute sensitivity of phase measurement in an SU(1,1) type interferometer(OSA, 2018) Du, Wei; Jia, Jun; Chen, J. F.; Ou, Z. Y.; Zhang, Weiping; Physics, School of ScienceAbsolute sensitivity is measured for the phase measurement in an SU(1,1) type interferometer, and the results are compared to that of a Mach–Zehnder interferometer operated under the condition of the same intra-interferometer intensity. The interferometer is phase locked to a point with the largest quantum noise cancellation, and a simulated phase modulation is added in one arm of the SU(1,1) interferometer. Both the signal and noise level are estimated at the same frequency range, and we obtained 3 dB improvement in sensitivity for the SU(1,1) interferometer over the Mach–Zehnder interferometer. Our results demonstrate a direct phase estimation and may pave the way for practical applications of a nonlinear interferometer.Item Accessible precisions for estimating two conjugate parameters using Gaussian probes(American Physical Society, 2020-05) Assad, Syed M.; Li, Jiamin; Liu, Yuhong; Zhao, Ningbo; Zhao, Wen; Lam, Ping Koy; Ou, Z. Y.; Li, Xiaoying; Physics, School of ScienceWe analyze the precision limits for a simultaneous estimation of a pair of conjugate parameters in a displacement channel using Gaussian probes. Having a set of squeezed states as an initial resource, we compute the Holevo Cramér-Rao bound to investigate the best achievable estimation precisions if only passive linear operations are allowed to be performed on the resource prior to probing the channel. The analysis reveals the optimal measurement scheme and allows us to quantify the best precision for one parameter when the precision of the second conjugate parameter is fixed. To estimate the conjugate parameter pair with equal precision, our analysis shows that the optimal probe is obtained by combining two squeezed states with orthogonal squeezing quadratures on a 50:50 beam splitter. If different importance is attached to each parameter, then the optimal mixing ratio is no longer 50:50. Instead, it follows a simple function of the available squeezing and the relative importance between the two parameters.Item Active learning pedagogy: Structuring the pre-instruction assignment(IOP, 2019) Novak, G.; Physics, School of ScienceEducation research is changing the way teachers teach and students learn. In contrast with the lecture-based approach to instruction, centered on the teacher as "performer", teaching and learning activities now place equal emphasis on in-class and out-of-class work. Much of the interaction between at-home activity and classroom experience and is mediated by information technology tools. Students are technology savvy, comfortable in the world of on-line delivery of information and social media interactions. To be an effective player in this world, instructional design has to follow the students. Contrary to the opinion that the introduction of technology into the teaching and learning process will diminish the role of the teacher, we believe that the opposite could be the case. Communication technology can enable all students to be exposed to the best and most charismatic lecturers. Electronically enabled social media forums can give rise to much more individualized interactions between students and instructors and students and students than what was ever possible. In this paper, we focus on some pedagogical approaches that allow the students to prepare themselves for interactive classroom engagement. The techniques we describe are labelled Just-in-Time Teaching and Worked-Examples. These involve carefully crafted assignments that students complete before going to class. The results of these assignments, completed just before class-time and available to the instructor, prepare the both for a more productive in-class experience.Item All n-3 PUFA are not the same: MD simulations reveal differences in membrane organization for EPA, DHA and DPA(Elsevier, 2018) Leng, Xiaoling; Kinnun, Jacob J.; Cavazos, Andres T.; Canner, Samuel W.; Shaikh, Saame Raza; Feller, Scott E.; Wassall, Stephen R.; Physics, School of ScienceEicosapentaenoic (EPA, 20:5), docosahexaenoic (DHA, 22:6) and docosapentaenoic (DPA, 22:5) acids are omega-3 polyunsaturated fatty acids (n-3 PUFA) obtained from dietary consumption of fish oils that potentially alleviate the symptoms of a range of chronic diseases. We focus here on the plasma membrane as a site of action and investigate how they affect molecular organization when taken up into a phospholipid. All atom MD simulations were performed to compare 1-stearoyl-2-eicosapentaenoylphosphatylcholine (EPA-PC, 18:0–20:5PC), 1-stearoyl-2-docosahexaenoylphosphatylcholine (DHA-PC, 18:0–22:6PC), 1-stearoyl-2-docosapentaenoylphosphatylcholine (DPA-PC, 18:0–22:5PC) and, as a monounsaturated control, 1-stearoyl-2-oleoylphosphatidylcholine (OA-PC, 18:0–18:1PC) bilayers. They were run in the absence and presence of 20 mol% cholesterol. Multiple double bonds confer high disorder on all three n-3 PUFA. The different number of double bonds and chain length for each n-3 PUFA moderates the reduction in membrane order exerted (compared to OA-PC, 𝑆̅𝐶𝐷 = 0.152). EPA-PC (𝑆̅𝐶𝐷 = 0.131) is most disordered, while DPA-PC ( 𝑆̅𝐶𝐷 = 0.140) is least disordered. DHA-PC (𝑆̅𝐶𝐷 = 0.139) is, within uncertainty, the same as DPA-PC. Following the addition of cholesterol, order in EPA-PC (𝑆̅𝐶𝐷 = 0.169), DHA-PC (𝑆̅𝐶𝐷 = 0.178) and DPA-PC (𝑆̅𝐶𝐷 = 0.182) is increased less than in OA-PC (𝑆̅𝐶𝐷 = 0.214). The high disorder of n-3 PUFA is responsible, preventing the n-3 PUFA-containing phospholipids from packing as close to the rigid sterol as the monounsaturated control. Our findings establish that EPA, DHA and DPA are not equivalent in their interactions within membranes, which possibly contributes to differences in clinical efficacy.Item Annihilation and Control of Chiral Domain Walls with Magnetic Fields(ACS, 2021-02-10) Karna, Sunil K.; Marshall, Madalynn; Xie, Weiwei; DeBeer-Schmitt, Lisa; Young, David P.; Vekhter, Ilya; Shelton, William A.; Kovács, Andras; Charilaou, Michalis; DiTusa, John F.; Physics, School of ScienceThe control of domain walls is central to nearly all magnetic technologies, particularly for information storage and spintronics. Creative attempts to increase storage density need to overcome volatility due to thermal fluctuations of nanoscopic domains and heating limitations. Topological defects, such as solitons, skyrmions, and merons, may be much less susceptible to fluctuations, owing to topological constraints, while also being controllable with low current densities. Here, we present the first evidence for soliton/soliton and soliton/antisoliton domain walls in the hexagonal chiral magnet Mn1/3NbS2 that respond asymmetrically to magnetic fields and exhibit pair-annihilation. This is important because it suggests the possibility of controlling the occurrence of soliton pairs and the use of small fields or small currents to control nanoscopic magnetic domains. Specifically, our data suggest that either soliton/soliton or soliton/antisoliton pairs can be stabilized by tuning the balance between intrinsic exchange interactions and long-range magnetostatics in restricted geometries.Item Anomalous Edge State in a Non-Hermitian Lattice(APS, 2016-04) Lee, Tony E.; Department of Physics, School of ScienceWe show that the bulk-boundary correspondence for topological insulators can be modified in the presence of non-Hermiticity. We consider a one-dimensional tight-binding model with gain and loss as well as long-range hopping. The system is described by a non-Hermitian Hamiltonian that encircles an exceptional point in momentum space. The winding number has a fractional value of 1/2. There is only one dynamically stable zero-energy edge state due to the defectiveness of the Hamiltonian. This edge state is robust to disorder due to protection by a chiral symmetry. We also discuss experimental realization with arrays of coupled resonator optical waveguides.Item Approaching single temporal mode operation in twin beams generated by pulse pumped high gain spontaneous four wave mixing(OSA, 2016-01) Liu, Nannan; Liu, Yuhong; Guo, Xueshi; Yang, Lei; Li, Xiaoying; Ou, Z. Y.; Department of Physics, School of ScienceBy investigating the intensity correlation function, we study the spectral/temporal mode properties of twin beams generated by the pulse-pumped high gain spontaneous four wave mixing (SFWM) in optical fiber from both the theoretical and experimental aspects. The results show that the temporal property depends not only on the phase matching condition and the filters applied in the signal and idler fields, but also on the gain of SFWM. When the gain of SFWM is low, the spectral/temporal mode properties of the twin beams are determined by the phase matching condition and optical filtering and are usually of multi-mode nature, which leads to a value larger than 1 but distinctly smaller than 2 for the normalized intensity correlation function of individual signal/idler beam. However, when the gain of SFWM is very high, we demonstrate the normalized intensity correlation function of individual signal/idler beam approaches to 2, which is a signature of single temporal mode. This is so even if the frequencies of signal and idler fields are highly correlated so that the twin beams have multiple modes in low gain regime. We find that the reason for this behavior is the dominance of the fundamental mode over other higher order modes at high gain. Our investigation is useful for constructing high quality multi-mode squeezed and entangled states by using pulse-pumped spontaneous parametric down-conversion and SFWM.Item Atom-Light Hybrid Interferometer(APS, 2015-07) Chen, Bing; Qiu, Shuying; Guo, Jinxian; Chen, L. Q.; Ou, Z. Y.; Zhang, Weiping; Department of Physics, School of ScienceA new type of hybrid atom-light interferometer is demonstrated with atomic Raman amplification processes replacing the beam splitting elements in a traditional interferometer. This nonconventional interferometer involves correlated optical and atomic waves in the two arms. The correlation between atoms and light developed with the Raman process makes this interferometer different from conventional interferometers with linear beam splitters. It is observed that the high-contrast interference fringes are sensitive to the optical phase via a path change as well as the atomic phase via a magnetic field change. This new atom-light correlated hybrid interferometer is a sensitive probe of the atomic internal state and should find wide applications in precision measurement and quantum control with atoms and photons.