Department of Human-Centered Computing

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    IUPUI New Media Animation Projects
    (2005-02-14T22:08:50Z) Wiser, Leslie
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    American Family Archive Project
    (2005-02-14T22:21:24Z) Wiser, Leslie
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    Fitness Training Guide
    (2005-03-21T16:38:14Z) Reed, David
    This interactive multi-media presentation guides the user through a fitness training regiment. It details specific excercises and muscle groups and discusses nutritional concerns.
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    UITS Communications & Planning Office: 2002-2003 Year in Review Portfolio
    (2005-07-21T20:40:15Z) Hoffman, James C.
    This is an interactive portfolio showcasing the work of the UITS Communications & Planning Office. The portfolio presents a sampling of projects completed during the 2002-2003 fiscal year.
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    Capstone 2003
    (2005-08-02) Nguyen, Diep (Christine) 1980-
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    Multiple vantage points of the common operational picture: Supporting International Teamwork
    (HFES Press, 2006) McNeese, Michael D.; Pfaff, Mark S.; Connors, Erik S.; Obieta, Joaquin F.; Terrell, Ivanna S.; Friedenberg, Marc A.
    This paper summarizes multiple perspectives of the common operational picture (COP) in military and civilian crisis management domains viewed from three vantage points: historical, conceptual, and practical. The term COP extends prior research on large group displays to describe a visual representation of tactical, operational, and strategic information intended to generate situation awareness. We present four strata of interest to formulate an innovative conceptual framework of the COP based on user-team needs: structure, representation, processes, and management. This conceptual framework is applied as part of a review of recent and ongoing projects that examines current research gaps in the application of geographic information systems (GIS) to international humanitarian response.
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    Dynamics of Co-Transcriptional Pre-mRNA Folding Influences the Induction of Dystrophin Exon Skipping by Antisense Oligonucleotides
    (PLOS, 2008-03-26) Wee, Keng Boon; Dwi Pramono, Zacharias Aloysius; Wang, Jian Li; MacDorman, Karl F.; Lai, Poh San; Yee, Woon Chee; Human-Centered Computing, School of Informatics and Computing
    Antisense oligonucleotides (AONs) mediated exon skipping offers potential therapy for Duchenne muscular dystrophy. However, the identification of effective AON target sites remains unsatisfactory for lack of a precise method to predict their binding accessibility. This study demonstrates the importance of co-transcriptional pre-mRNA folding in determining the accessibility of AON target sites for AON induction of selective exon skipping in DMD. Because transcription and splicing occur in tandem, AONs must bind to their target sites before splicing factors. Furthermore, co-transcriptional pre-mRNA folding forms transient secondary structures, which redistributes accessible binding sites. In our analysis, to approximate transcription elongation, a “window of analysis” that included the entire targeted exon was shifted one nucleotide at a time along the pre-mRNA. Possible co-transcriptional secondary structures were predicted using the sequence in each step of transcriptional analysis. A nucleotide was considered “engaged” if it formed a complementary base pairing in all predicted secondary structures of a particular step. Correlation of frequency and localisation of engaged nucleotides in AON target sites accounted for the performance (efficacy and efficiency) of 94% of 176 previously reported AONs. Four novel insights are inferred: (1) the lowest frequencies of engaged nucleotides are associated with the most efficient AONs; (2) engaged nucleotides at 3′ or 5′ ends of the target site attenuate AON performance more than at other sites; (3) the performance of longer AONs is less attenuated by engaged nucleotides at 3′ or 5′ ends of the target site compared to shorter AONs; (4) engaged nucleotides at 3′ end of a short target site attenuates AON efficiency more than at 5′ end.
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    The Influence of Holistic and Analytic Cognitive Styles on Online Information Design: Toward a communication theory of cultural cognitive design
    (2008-04) Faiola, Anthony; MacDorman, Karl F.
    Although studies have linked culture to online user preferences and performance, few communication researchers have recognized the impact of culture on online information design and usability. It is important to ask if people are better able to use and prefer Web sites created by designers from their own culture. We propose that to improve computer-mediated communication, Web site design should accommodate culturally diverse user groups. First, a body of research is presented that aligns East Asian cultures with more holistic cognitive styles and Western cultures with more analytical cognitive styles. Building on this contrast, a theory of cultural cognitive design is proposed as a means of understanding how cognitive styles that develop under the influence of culture lead to different ways of designing and organizing information for the Web.
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    Mega-Collaboration: The inspiration and development of an interface for large-scale disaster response.
    (2009) Pfaff, Mark; Newlon, Christine; Patel, Himalaya; Vreede, Gert-Jan de; MacDorman, Karl F.