IUPUI Research Day 2011

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Renal Cyst Fluid From Human Polycystic Kidney Disease Patients Stimulates Cl- Transport: Active Factor and Cl- Channels
(Office of the Vice Chancellor for Research, 2011-04-08) Blazer-Yost, Bonnie L.; Blacklock, Brenda; Bacallao, Robert L.; Gattone, Vincent H.
Autosomal dominant polycystic kidney disease (ADPKD) is characterized by the slow growth of fluid-filled cysts predominately in the kidney and in liver bile ducts. The factors involved in modifying the rate of cyst growth through epithelial proliferation or secretion are critical to understanding the progression of the disease. In addition, elucidation of mechanisms that potentiate the normal progression to renal failure will provide the basis for therapeutic intervention. Of note are the observations that the decline in renal function in middle age is precipitous and that renal injury results in an exacerbation of cyst growth. Using electrophysiological and biochemical techniques, we identified LPA (lysophosphatic acid) as a component of cyst fluid that stimulates secretory Cl- transport via two anion channels, CFTR and TMEM16a, in the mpkCCDcl4 model of renal principal cells. The LPA effect is manifested through receptors located on the basolateral membrane of polarized renal cells resulting in stimulation of channel activity in the apical membrane. Concentrations of LPA measured in ADPKD cyst fluid and in normal serum are sufficient to maximally stimulate ion transport. Thus, cyst fluid seepage into the interstitial space and/or leakage of vascular LPA are capable of stimulating epithelial cell secretion resulting in cyst enlargement. Research Support: IUPUI Membrane Biosciences Signature Center Grant
International Collaboration Between IUPUI and ATilim University
(Office of the Vice Chancellor for Research, 2011-04-08) Kelceoglu, Bekir
This is an international collaboration project between IUPUI's Interior Design and ATilim University's Interior Architecture programs. We are trying to design medical stations (triage stations) for disaster areas by using three used shipping containers. Students from both countries are collaborating using various technology.
SOCIAL CHANGE THROUGH SOCIAL MOVEMENTS
(Office of the Vice Chancellor for Research, 2011-04-08) Taylor, Alexis C.
Through studying the interworkings of social movements and how they alter the perceptions of the mainstream society this study looks to investigate how social movements create social change. This study explores four different social movements spanning multiple decades to see what elements amongst all of them are consistent and what elements differ. The four social movements chosen are: the Civil Rights Movement, the Lesbian, Gay, Bisexual, and Transgendered (LGBT) Movement, the Hip-Hop Movement and the Marijuana Legalization Movement. These four movements are used as a general basis to represent not only the similarities and differences of social movements, but also to represent the struggle that all social movements face to gain acceptance socially, culturally, and politically in the mainstream. The study also looks to examine how movements use tools, specifically media, to gain momentum and become more widespread throughout the populations. The media that I look at as wielded by social movements to display their message range from radio and newspapers to more modern devices of media such as television and internet. I look forward to advancing my research on social change and the catalysts that enable it and hope to compound on my research especially the power of media aspect and investigate psychological implications of media for social change.
The appearance, speech, and motion of synthetic humans influences our empathy toward them
(Office of the Vice Chancellor for Research, 2011-04-08) MacDorman, Karl F.; Ho, Chin-Chang; Lu, Amy S.; Mitchell, Wade J.; Patel, Himalaya; Srinivas, Preethi; Schermerhorn, Paul W.; Scheutz, Matthias
Humanoid robots and computer-generated humans can elicit responses that people usually direct toward each other. As a result these humanlike entities may stand in for human actors during experiment-driven research in the social and psychological sciences as well as in some branches of neuroscience. Such research concerns factors like facial appearance, physical embodiment, speech quality, fluidity of motion, and contingent interactivity. A goal of this research is to understand why some humanlike entities are more successful than others at eliciting people’s empathy. Pursuing this goal informs new principles for creating synthetic humans that seem more believable in narratives and narrative-based interventions.
Living Lab in Computer Information Technology
(Office of the Vice Chancellor for Research, 2011-04-08) Justice, Connie
Research Subject is the Living Lab in CIT, an experiential learning environment where students gain real IT experience.The Living Lab allows students to apply networking, security, database, website, and application development concepts and techniques learned from prior CIT courses to internal and/or external projects. The Living Lab emulates an industry IT department in which students work on one or more projects as part of an IT team.
Proteomic Techniques in the Physiological Proteomics Core Facility
(Office of the Vice Chancellor for Research, 2011-04-08) Lai, Xianyin; Witzmann, Frank A.
A new software package, IdentiQuantXL, has been developed in the Physiological Proteomics Core Facility to provide large-scale protein identification and label-free quantification using either low or high resolution LC-MS/MS data. Though many software packages have been developed to perform label-free quantification of proteins in complex biological samples using peptide intensities generated by liquid chromatography - tandem mass spectrometry (LC-MS/MS), two important issues hinder the use of peptide intensity measurements: (i) It is difficult to accurately determine the retention time of each peptide peak, especially for low resolution data, and (ii) many peptides cannot be used for protein quantification. To address these two key issues, we have developed a new method to enable accurate peptide peak retention time determination and multiple filters to eliminate unqualified peptides for protein quantification. Repeatability and linearity have been tested using ion trap-derived low resolution data from six very different samples, i.e., standard peptides, kidney tissue lysates, HT29-MTX cell lysates, depleted human serum, human serum albumin-bound proteins, and standard proteins spiked in kidney tissue lysates. In all these unique experiments, at least 90.8% of proteins (up to 1,390) had CVs ≤ 3 0% across 10 technique replicates, and at least 92.1% of proteins (up to 2,013) had R2 ≥ 0.9500 across 7 concentrations. The performance of our strategy was verified using identical amounts of standard protein (lysozyme) spiked in complex biological samples (cell culture media containing secreted proteins) with a CV of 8.6% across eight injections. The excellent performance was further confirmed by comparing label-free mass spectrometry to Western blot detection of prolactin, which was decreased 17.1fold in dwarfed mice compared to wild-type using the label-free quantification strategy and very low or undetectable using Western blot. The results indicate that our new platform, named IdentiQuantXL, accurately quantifies thousands of peptides and proteins in complex samples. It has been applied in the aqueous humor proteome in patients with Fuchs endothelial corneal dystrophy. While many software packages focus only on high resolution data, our strategy is designed for both high and low resolution data. Consequently, it is very useful for data generated by low resolution mass spectrometers such as the LTQ, especially when the dynamic exclusion of ions in data acquisition is enabled to obtain more MS/MS fragments of low-abundance peptides to maximally identify proteins in a complex biological sample. Supported by NIEHS RC2ES018810 and NIGMS R01GM085218
Indiana CTSI Research Recruitment Office
(Office of the Vice Chancellor for Research, 2011-04-08) Hudson, Brenda
The Indiana CTSI Research Recruitment Office was designed to engage and empower the public in health research. We also work to inform Health Care Providers about research opportunities for their patients, develop collaborative relationships with industry and organizational partners and provide support through infrastructure, services, and opportunities to the research community at the various institutions associated with the Indiana CTSI. By working from within the Indiana CTSI, we can help link people with the best resources for research recruitment. Whether you are an Indiana resident looking to participate in a study, a Health Care Provider trying to identify a research study for a patient, a researcher trying to find participants, or an industry partner trying to build collaborations, we can help!
Institute for American Thought
(Office of the Vice Chancellor for Research, 2011-04-08) Pfeifer, David
This poster will have images of recent volumes published by the critical editions being edited by the Institute for American Thought. Information will tell how long the critical editions have been in existence, how much funding has been received. The new fifth critical edition will be mentioned. We will provide information on our five scholarly critical editions. Three of them publish the works of the classical American philosophers Charles S. Peirce (1839–1914), Josiah Royce (1855– 1916), and George Santayana (1863–1952), and two others the works of the famous abolitionist Frederick Douglass (1818–1895), and the short stories of Ray Bradbury (1920–).
THE PREDICTIVE UTILITY OF ECOLOGICAL MOMENTARY ASSESSMENT MEASURES VERSUS RETROSPECTIVE SELFREPORT MEASURES: A QUALITATIVE LITERATURE REVIEW
(Office of the Vice Chancellor for Research, 2011-04-08) Zielke, Desiree J.
Proponents of ecological momentary assessment (EMA), in which repeated measures of variables are obtained in real-time from individuals in their environment, have asserted that the reliability and validity of self-reports obtained by this method are superior to those obtained by traditional retrospective assessments. Because this claim has not been adequately evaluated, we conducted a qualitative literature review to address the following question related to this assertion: Is the predictive utility of EMA self-reports superior to that of retrospective self-reports? We searched MedLine and PsycInfo for studies that obtained both EMA measures and retrospective measures of the same construct and examined the ability of EMA and retrospective measures to predict the same outcome. Eight studies were identified. One study examined two separate outcomes and therefore results are presented based on 9 findings. The studies revealed that EMA measures were stronger predictors of the outcome than retrospective measures in 5 (56%) findings. In 2 (22%) findings, retrospective measures outperformed EMA measures. Results of 2 findings were equivocal. In sum, the bulk of the evidence provides preliminary support for the notion that EMA measures have superior predictive utility as compared to retrospective measures; however, the type of outcome (biological vs. behavioral/subjective) may influence the pattern of results. There is a clear need for research to determine in which situations EMA or retrospective measures are stronger predictors of outcomes.
Indianapolis Event Tourism: Culture and sport perspectives
(Office of the Vice Chancellor for Research, 2011-04-08) King, C.; Hji-Avgoustis, S.; Wang, S.
Cities rely on urban tourism for economic regeneration and strategic development (Ioannides & Peterson, 2003; Law, 2002; Rogerson, 2004). Depending on how it is calculated, tourism is Indianapolis’s third- or fourth-largest industry, with an estimated economic impact of about $3.56 billion a year. Cultural and sports activities that are attractive to special event attendees include: sports events, festivals or fairs, group tours, trade shows, and cultural attractions, such as museums, plays, concerts, etc. The purpose of the study was to investigate Indianapolis residents’ perceptions of the importance of event tourism, via culture and sports, and their willingness to sustain each segment using public financing. A total of 16 urban cultural tourism development attributes and 16 sports tourism development attributes were adapted from a study by Wang, Fu, Cecil, and Hji-Avgoustis (2008). The 16 items were measured on a fivepoint Likert scale ranging from “strongly agree” to “strongly disagree”. Data was collected in September 2010 via convenience sampling in eight pre-selected locations in Indianapolis. Several sports and cultural events such as the Irish festival and a canoe regatta had been held in those locations. A total of 380 surveys were used for analysis. This is a case study and the generalizability of the findings is limited. Based on the paired sample t-tests, residents’ perceptions about sports tourism vs cultural tourism were significantly different on 13 of the 16 items. The biggest discrepancies of mean ratings were found in pair 1 (accomplishment awareness), pair 10 (related offerings awareness), pair 2 (city plans awareness) and pair 3 (potential to succeed). For these four pairs, sport items were more positively perceived than cultural items. There was moderate correlation between ‘accomplishment awareness’ and ‘potential to succeed’, ‘accomplishment awareness’ and ‘positive image creation’, and ‘accomplishment awareness’ and ‘good for economy’ in terms of both cultural tourism and sport tourism. The results indicate that more accomplishments achieved by the city, either in cultural tourism or sport tourism, may more likely make residents feel and acknowledge the importance and benefit of cultural tourism and sport tourism development and thus become more positive in supporting tourism or sport-related initiatives. As for city event tourism planners, one important task may be to make known to the public every achievement made in the areas of cultural and sports tourism. Coccossis (2009) described a qualitative shift in tourist demand where education, culture and activities which engage the visitor in local events and lifestyle are gaining importance. Hence in planning for the future, Indianapolis could pre-emptively provide a relatively richer diversity of cultural offerings in comparison to sports offerings, to carve a competitive edge to meet the evolving demands of visitor experiences.

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