IUPUI Research Day 2014

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https://hdl.handle.net/1805/4256

A program book describing the Research Day 2014 events and posters is available from: http://hdl.handle.net/1805/4257.

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Authors' Rights to Share Scholarship: A Survey of IUPUI Faculty Attitudes
(2014-04-11) Odell, Jere D.; Dill, Emily; Palmer, Kristi L.
Faculty who take an active role in the dissemination of their research are more likely to make an impact on a field of scholarship. Online, full text archiving is a key component of being a self-advocate and for building a scholarly reputation. In fact, posting a version of a published article in an open access repository, such as IUPUI ScholarWorks, increases an author’s citation rate. Most journal publishers (72%) permit authors to upload a version of their article to IUPUI ScholarWorks; however, faculty may be unsure of how to exercise this right. Do IUPUI faculty self-archive their articles? Do they examine or negotiate the terms of their copyright transfer agreements? Would IUPUI faculty consider implementing a campus policy to maximize their rights as authors? To explore attitudes related to these questions, we conducted a campus-wide survey of IUPUI faculty in the Fall semester of 2013. The survey adapted an instrument used in similar campus-wide research conducted in 2006 at the University of California and in 2010 at the University of Toronto. This broad survey addressed attitudes regarding many factors relevant to publishing, peer review and scholarly communications. Here we report preliminary results pertaining to author’s rights, self-archiving practices and open access policies. Results: Complete responses (n=248); Partial responses (n=90). Author’s Rights: Most faculty (54%) consider the right to self-archive as a factor in selecting a journal for publication. A few have refused to sign a copyright transfer agreement (n=16) and a few have modified contracts (n=10). Most (68%) support a campus discussion of copyright management. Likewise, faculty would appreciate instructions and models for copyright negotiations (65%) as well as more formal institutional support for retaining rights (61%). Self-Archiving: Although nearly half had heard of IUPUI ScholarWorks (45%), only 25% of the respondents reported submitting a work to an institutional repository. Faculty were most influenced to self-archive by the motivation to support the dissemination of academic research in general (n=151), by increased exposure (n=149), and by the norms of their academic unit (n=102). Open Access Policies: The majority of faculty (72%) were unfamiliar with institutional open access policies such as those at Harvard, MIT, Duke and Kansas. When asked, however, if IUPUI should consider implementing a similar policy, 52% were unsure, 39% were supportive and only 9% disagreed.
IUPUI Research Day 2014. Research and Creative Activity Matter: From IUPUI to the World
(2014-04-11) Office of the Vice Chancellor for Research, IUPUI
The Effect of Retinoids on the Regenerating Axolotl Spinal Cord
(2014-04-11) Kirk, Maia P.; Chernoff, Ellen A.G.
In order to further elucidate the mechanics of the retinoid pathway on Urodele spinal cord regeneration, we employed Antibody/Horseradish Peroxidase Staining of both intact and regenerating Axolotl spinal cord tissues obtained from adult and juvenile animals to determine expression of two retinoid pathway components: Cellular Retinoic Acid Binding Protein II (CRABP II) and Cellular Retinol Binding Protein I (CRBP I). Current results demonstrate that CRABP II is heavily expressed in the arachnoid mater meningeal layer; CRPB I, however, is expressed in the following locations: the pia mater meningeal layer, the nuclei and cytoplasm of gray matter neuroblasts, as well as processes derived from neuroblasts and ependyma. Moreover, the morphogenic nature of the retinoids may possess a significant role in the regeneration-permissive interaction of the meninges and ependyma of the Axolotl spinal cord.
Effects of GSK3-β Inhibitors on Wnt Signaling in Zebrafish Fin Regeneration: Chemical Biology
(2014-04-11) Brannick, Angelica; Mahin, Jennifer L.; Farrel, Mark; Curtis, Courtney; Sarmah, Swapnalee; Collins, Kayla; Chu, Shaoyou; Sato, Mas; Sanchez-Felix, Manuel
In order to develop beneficial drugs for osteoporosis it is important to understand the molecular mechanisms of bone regeneration and define specific regulatory factors. Zebrafish can regenerate damaged tissues, and they prove to be a good model to study bone growth and repair. Previous research showed that GSK3β inhibitor compound at various concentrations and for different treatment periods effectively stimulated fin regeneration. Conducted experiments identified temporal and spatial fluctuations on individual gene markers after GSK3β inhibitor treatment at various concentrations. Recent analyzed data uses the Lilly Research Labs experimental compound LSN 2105786 at 3 nM and 5 nM to stimulate tissue regeneration to determine whether activating Wnt signaling produces cell proliferation and β-catenin translocation to the nucleus for zebrafish bone regeneration. This research has potential to identify mechanism of bone growth and repair, leading to more suitable drugs for patients suffering with osteoporosis.
“Cuando actuamos, actuamos juntos”: Understanding the intersections of religion, activism, and citizenship within the Latino community in Indianapolis
(2014-04-11) Logan, Ryan I.
Undocumented immigration from Latin America is a heated and divisive topic in United States' politics. Politicians in Washington, D.C. are debating new legislation which would provide a pathway to citizenship for some 11 million undocumented immigrants. The Indianapolis Congregation Action Network (IndyCAN), a grassroots activist group in Indianapolis, is organizing the Latino community through faith and shared political goals. Many undocumented Latino immigrants are utilizing IndyCAN to mobilize and attempt to influence progressive policy change. However, nativist groups challenge these efforts by trying to define who can be considered an "American" and are attempting to block legislation due to their negative perceptions of Latinos. Debates about citizenship reveal the embeddedness of race and ethnicity in defining “American.” Despite this, many Latino immigrants are forging their own identities in the United States and are engaging in a political system which refuses to grant them a legal status. Within IndyCAN, this political involvement occurs through religious strategies that seem apolitical yet are implicitly an enactment of activism. This project reveals how undocumented Latino immigrants in Indianapolis are impacting the political process regardless of their legal status.
Listening through seeing: Using design methods to learn about the health perceptions of Garden on the Go® customers
(2014-04-11) Sanematsu, Helen; Hong, Youngbok; Cole, Lisa; Zollinger, Terrell
The goal of this project is to apply an innovative approach to gathering beliefs and attitudes of an inner city population in a more valid and reliable way than traditional data collection methods. This community based research study will focus on dietary risk factors for obesity, diabetes type 2, and cardiovascular disease in underserved communities. Our study assesses what health means to the underserved Garden on the Go® clients and how they define a healthy diet. Garden on the Go®, a signature obesity prevention effort, is Indiana University Health’s year-round mobile produce delivery program providing fresh, affordable produce to Marion County neighborhoods in need. We build upon previous research conducted with Garden on the Go® to enhance the effectiveness of this intervention and provide valuable information that other groups may use to improve the impact of their efforts in meeting the health needs of similar communities.
Mining the Indianapolis Recorder: An Exploratory Study of a Digital Humanities Dataset
(2014-04-11) Polley, David E.; Coates, Heather L.; Johnson, Jennifer; Odell, Jere D.; Palmer, Kristi L.
This poster presents an initial study using full-text transcripts from the Indianapolis Recorder, one of the nation's most important African American newspapers. Basic text mining and visualization approaches are used to highlight this data set and its potential for use in the digital humanities.
Community Engagement: Evaluation of the JPMorgan Chase Foundation - IUPUI Near Eastside Legacy Initiative
(2014-04-11) Garcia, Silvia; Bennett, Teresa; Fitzpatrick, Christine
In early 2011, the IUPUI Solution Center received a $75,000, two-year grant from the JPMorgan Chase Foundation to facilitate faculty and student involvement in the Near Eastside of Indianapolis to promote community health and wellness. The project emerged from the community’s stated need to increase efforts that improve the overall health and fitness and provide affordable access to fitness, wellness, educational opportunities and health-related resources to residents of the Near Eastside. A comprehensive assessment to measure the program efficacy, cost-effectiveness and impact yielded that the JPMorgan Chase Foundation – IUPUI Near Eastside Legacy Initiative (CHASE/NELI) increased awareness of and activity in the Chase Near Eastside Legacy Center and promoted health and wellness, through targeted communication and public health awareness strategies.
3D Assessment of Nasopharyngeal and Craniofacial Phenotypes in Ts65Dn Down Syndrome Mice Treated with a Dyrk1a Inhibitor
(2014-04-11) Starbuck, John M.; Harrington, Emily; Kula, Katherine S.; Ghoneima, Ahmed A.; Roper, Randall J.
Background: Down syndrome (DS) originates from having three copies of chromosome 21 (i.e. Trisomy 21). DS is associated with many detrimental phenotypes including intellectual disabilities, heart defects, abnormal craniofacial development, and obstructive sleep apnea, which develops from restricted nasopharyngeal airways and an underdeveloped mandible. Ts65Dn mice are trisomic for about half of the orthologs on human chromosome 21 and display many phenotypes associated with DS including craniofacial abnormalities. Dyrk1a is found in three copies in Ts65Dn mice and individuals with DS, and thought to be a root cause of the craniofacial phenotypes. Epigallocatechin 3-gallate (EGCG) is a green tea polyphenol and inhibitor of Dyrk1a activity. Purpose: We hypothesize that decreased Dyrk1a activity in Ts65Dn mice will ameliorate craniofacial dysmorphology. Methods: To test our hypothesis we compared Ts65Dn mice with two or three copies of Dyrk1a and compared Ts65Dn mice with and without prenatal EGCG treatment. EGCG treated mothers were fed 200mg/kg EGCG on gestational day 7. Six week old mice were sacrificed and their heads imaged using micro-computed tomography (μCT). From μCT images, we measured nasopharyngeal airway volume and anatomical landmarks (n = 54) from the facial skeleton, cranial vault, cranial base, and mandible. Mean nasopharyngeal airway volumes were graphically compared, and a landmark-based multivariate geometric morphometric approach known as Euclidean Distance Matrix Analysis (EDMA) was carried out to assess local differences in craniofacial morphology between trisomic mouse samples. Results: Our preliminary results indicate that EGCG treatment and reduced Dyrk1a copy number increases mean nasopharyngeal airway volume in Ts65Dn mice. Craniofacial morphometric differences were found among all samples. EGCG treatment increased portions of the mandible and decreased portions of the cranial vault and cranial base. Conclusion: Preliminary analyses suggest that both EGCG treatment and reduced Dyrk1a copy number affect craniofacial morphology.
DNA/RNA Degradation Rate in Long Term Fixed Museum Specimens
(2014-04-11) Cook, Shannon; Dodge, Chelsea; Morgan, Randy; Sandusky, George E.
In today’s research driven society, it has become commonplace for institutions to rely upon DNA and RNA extraction techniques to help obtain genomic data from old specimens. Generally, specimens were commonly preserved for future gross examination and/or teaching. Using histological examination of specimens from museum jars from the Pathology Department at the Indiana University School of Medicine, the sequential and chronological degradation of DNA and RNA has been studied. We examined gross specimens from nine decades from 1920 until 2000. We evaluated histologic preservation of kidney, liver, heart, lung, spleen, uterus, and brain for nuclear structure in these samples. Nuclear preservation was based on amount of nuclei per 20x microscopic field and the crispness of the nuclear membrane and internal features. The nuclei in high lipid tissues such as the brain were found to degrade at a quicker rate than dense tissues such as the heart and uterus. Our study has shown specimens preserved beyond fifty years were likely to have little to no nuclei left, thus indicating that there was little to no DNA and RNA remaining. This technique of histologic evaluation first is an important finding and a general guideline which may save research institutions from the expensive process of DNA and RNA extraction.

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