Impact of Oxidative Stress on Risk of Death and Readmission in African Children With Severe Malaria: A Prospective Observational Study
dc.contributor.author | Blatt, Daniel B. | |
dc.contributor.author | Hanisch, Benjamin | |
dc.contributor.author | Co, Katrina | |
dc.contributor.author | Datta, Dibyadyuti | |
dc.contributor.author | Bond, Caitlin | |
dc.contributor.author | Opoka, Robert O. | |
dc.contributor.author | Cusick, Sarah E. | |
dc.contributor.author | Michelow, Ian C. | |
dc.contributor.author | John, Chandy C. | |
dc.contributor.department | Pediatrics, School of Medicine | |
dc.date.accessioned | 2023-10-31T13:31:05Z | |
dc.date.available | 2023-10-31T13:31:05Z | |
dc.date.issued | 2022 | |
dc.description.abstract | Background: We hypothesized that oxidative stress in Ugandan children with severe malaria is associated with mortality. Methods: We evaluated biomarkers of oxidative stress in children with cerebral malaria (CM, n = 77) or severe malarial anemia (SMA, n = 79), who were enrolled in a randomized clinical trial of immediate vs delayed iron therapy, compared with community children (CC, n = 83). Associations between admission biomarkers and risk of death during hospitalization or risk of readmission within 6 months were analyzed. Results: Nine children with CM and none with SMA died during hospitalization. Children with CM or SMA had higher levels of heme oxygenase-1 (HO-1) (P < .001) and lower superoxide dismutase (SOD) activity than CC (P < .02). Children with CM had a higher risk of death with increasing HO-1 concentration (odds ratio [OR], 6.07 [95% confidence interval {CI}, 1.17-31.31]; P = .03) but a lower risk of death with increasing SOD activity (OR, 0.02 [95% CI, .001-.70]; P = .03). There were no associations between oxidative stress biomarkers on admission and risk of readmission within 6 months of enrollment. Conclusions: Children with CM or SMA develop oxidative stress in response to severe malaria. Oxidative stress is associated with higher mortality in children with CM but not with SMA. | |
dc.eprint.version | Final published version | |
dc.identifier.citation | Blatt DB, Hanisch B, Co K, et al. Impact of Oxidative Stress on Risk of Death and Readmission in African Children With Severe Malaria: A Prospective Observational Study. J Infect Dis. 2022;226(4):714-722. doi:10.1093/infdis/jiac234 | |
dc.identifier.uri | https://hdl.handle.net/1805/36805 | |
dc.language.iso | en_US | |
dc.publisher | Oxford University Press | |
dc.relation.isversionof | 10.1093/infdis/jiac234 | |
dc.relation.journal | The Journal of Infectious Diseases | |
dc.rights | Publisher Policy | |
dc.source | PMC | |
dc.subject | Plasmodium falciparum | |
dc.subject | Cerebral malaria | |
dc.subject | Child | |
dc.subject | Heme oxygenase-1 | |
dc.subject | Malaria | |
dc.subject | Malondialdehyde | |
dc.subject | Oxidative stress | |
dc.subject | Severe malarial anemia | |
dc.subject | Superoxide dismutase | |
dc.title | Impact of Oxidative Stress on Risk of Death and Readmission in African Children With Severe Malaria: A Prospective Observational Study | |
dc.type | Article | |
ul.alternative.fulltext | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9890907/ |