Meteorin-like promotes heart repair through endothelial KIT receptor tyrosine kinase
dc.contributor.author | Reboll, Marc R. | |
dc.contributor.author | Klede, Stefanie | |
dc.contributor.author | Taft, Manuel H. | |
dc.contributor.author | Cai, Chen-Leng | |
dc.contributor.author | Field, Loren J. | |
dc.contributor.author | Lavine, Kory J. | |
dc.contributor.author | Koenig, Andrew L. | |
dc.contributor.author | Fleischauer, Jenni | |
dc.contributor.author | Meyer, Johann | |
dc.contributor.author | Schambach, Axel | |
dc.contributor.author | Niessen, Hans W. | |
dc.contributor.author | Kosanke, Maike | |
dc.contributor.author | van den Heuvel, Joop | |
dc.contributor.author | Pich, Andreas | |
dc.contributor.author | Bauersachs, Johann | |
dc.contributor.author | Wu, Xuekun | |
dc.contributor.author | Zheng, Linqun | |
dc.contributor.author | Wang, Yong | |
dc.contributor.author | Korf-Klingebiel, Mortimer | |
dc.contributor.author | Polten, Felix | |
dc.contributor.author | Wollert, Kai C. | |
dc.contributor.department | Pediatrics, School of Medicine | |
dc.date.accessioned | 2024-01-17T13:31:28Z | |
dc.date.available | 2024-01-17T13:31:28Z | |
dc.date.issued | 2022 | |
dc.description.abstract | Effective tissue repair after myocardial infarction entails a vigorous angiogenic response, guided by incompletely defined immune cell-endothelial cell interactions. We identify the monocyte- and macrophage-derived cytokine METRNL (meteorin-like) as a driver of postinfarction angiogenesis and high-affinity ligand for the stem cell factor receptor KIT (KIT receptor tyrosine kinase). METRNL mediated angiogenic effects in cultured human endothelial cells through KIT-dependent signaling pathways. In a mouse model of myocardial infarction, METRNL promoted infarct repair by selectively expanding the KIT-expressing endothelial cell population in the infarct border zone. Metrnl-deficient mice failed to mount this KIT-dependent angiogenic response and developed severe postinfarction heart failure. Our data establish METRNL as a KIT receptor ligand in the context of ischemic tissue repair. | |
dc.eprint.version | Author's manuscript | |
dc.identifier.citation | Reboll MR, Klede S, Taft MH, et al. Meteorin-like promotes heart repair through endothelial KIT receptor tyrosine kinase. Science. 2022;376(6599):1343-1347. doi:10.1126/science.abn3027 | |
dc.identifier.uri | https://hdl.handle.net/1805/38041 | |
dc.language.iso | en_US | |
dc.publisher | American Association for the Advancement of Science | |
dc.relation.isversionof | 10.1126/science.abn3027 | |
dc.relation.journal | Science | |
dc.rights | Publisher Policy | |
dc.source | PMC | |
dc.subject | Adipokines | |
dc.subject | Cytokines | |
dc.subject | Heart failure | |
dc.subject | Macrophages | |
dc.subject | Myocardial infarction | |
dc.subject | Nerve growth factors | |
dc.title | Meteorin-like promotes heart repair through endothelial KIT receptor tyrosine kinase | |
dc.type | Article |