Nutritional Status and Lung Function in Children with Pancreatic-Sufficient Cystic Fibrosis
dc.contributor.author | Madde, Ankitha | |
dc.contributor.author | Okoniewski, Will | |
dc.contributor.author | Sanders, Don B. | |
dc.contributor.author | Ren, Clement L. | |
dc.contributor.author | Weiner, Daniel J. | |
dc.contributor.author | Forno, Erick | |
dc.contributor.department | Pediatrics, School of Medicine | |
dc.date.accessioned | 2024-03-15T09:06:35Z | |
dc.date.available | 2024-03-15T09:06:35Z | |
dc.date.issued | 2022 | |
dc.description.abstract | Background: There is a strong association between nutrition and long-term FEV1 in cystic fibrosis (CF), but studies have been driven by data from subjects with pancreatic insufficiency (PI-CF). We thus evaluated the association between body mass index (BMI) and FEV1 percent-predicted (FEV1pp) in children with pancreatic sufficiency (PS-CF) and contrasted it with the association in PI-CF. Methods: We utilized data from the CF Foundation Patient Registry. The cohort included children born 1995-2010, diagnosed <2 years of age, and who had annualized data on BMI percentile and FEV1pp at ages 6-16 years. Pancreatic status was defined based on pancreatic enzyme replacement therapy. The association between BMI and FEV1 was evaluated using linear and mixed-effects longitudinal regression. Results: There were 424 children with PS-CF and 7,849 with PI-CF. The association between BMI and FEV1 differed significantly by pancreatic status: each 10-pct higher BMI was associated with 2% [95%CI = 1.9-2.1] higher FEV1pp in PI-CF, compared to just 0.9% [0.5-1.3] in PS-CF (PINTERACTION < 0.001). Within the at-risk nutritional category (BMI <25pct), each 10-pct higher BMI was associated with 5% higher FEV1pp in PI-CF, but no significant increase in PS-CF. Moreover, in PS-CF, overweight/obesity (BMI ≥85pct) was associated with decreasing FEV1pp. In addition, FEV1pp decline through age 20 years in youth with PS-CF was modest (-0.6% per year) and independent of BMI (BMI*age PINTERACTION = 0.37). Conclusions: In children with PS-CF, BMI remains an important determinant of lung function. However, it may be less critical to attain a BMI >50th percentile; and BMI ≥85th percentile may be detrimental. | |
dc.eprint.version | Author's manuscript | |
dc.identifier.citation | Madde A, Okoniewski W, Sanders DB, Ren CL, Weiner DJ, Forno E. Nutritional status and lung function in children with pancreatic-sufficient cystic fibrosis. J Cyst Fibros. 2022;21(5):769-776. doi:10.1016/j.jcf.2021.12.014 | |
dc.identifier.uri | https://hdl.handle.net/1805/39261 | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | |
dc.relation.isversionof | 10.1016/j.jcf.2021.12.014 | |
dc.relation.journal | Journal of Cystic Fibrosis | |
dc.rights | Publisher Policy | |
dc.source | PMC | |
dc.subject | Cystic fibrosis | |
dc.subject | Nutrition | |
dc.subject | Pancreatic insufficiency | |
dc.subject | BMI | |
dc.subject | Lung function | |
dc.title | Nutritional Status and Lung Function in Children with Pancreatic-Sufficient Cystic Fibrosis | |
dc.type | Article |