Whole Blood, Fixed Ratio, or Goal-Directed Blood Component Therapy for the Initial Resuscitation of Severely Hemorrhaging Trauma Patients: A Narrative Review

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dc.contributor.authorWalsh, Mark
dc.contributor.authorMoore, Ernest E.
dc.contributor.authorMoore, Hunter B.
dc.contributor.authorThomas, Scott
dc.contributor.authorKwaan, Hau C.
dc.contributor.authorSpeybroeck, Jacob
dc.contributor.authorMarsee, Mathew
dc.contributor.authorBunch, Connor M.
dc.contributor.authorStillson, John
dc.contributor.authorThomas, Anthony V.
dc.contributor.authorGrisoli, Annie
dc.contributor.authorAversa, John
dc.contributor.authorFulkerson, Daniel
dc.contributor.authorVande Lune, Stefani
dc.contributor.authorSjeklocha, Lucas
dc.contributor.authorTran, Quincy K.
dc.contributor.departmentMedicine, School of Medicineen_US
dc.date.accessioned2022-05-10T16:28:07Z
dc.date.available2022-05-10T16:28:07Z
dc.date.issued2021-01-17
dc.description.abstractThis narrative review explores the pathophysiology, geographic variation, and historical developments underlying the selection of fixed ratio versus whole blood resuscitation for hemorrhaging trauma patients. We also detail a physiologically driven and goal-directed alternative to fixed ratio and whole blood, whereby viscoelastic testing guides the administration of blood components and factor concentrates to the severely bleeding trauma patient. The major studies of each resuscitation method are highlighted, and upcoming comparative trials are detailed.en_US
dc.eprint.versionFinal published versionen_US
dc.identifier.citationWalsh M, Moore EE, Moore HB, et al. Whole Blood, Fixed Ratio, or Goal-Directed Blood Component Therapy for the Initial Resuscitation of Severely Hemorrhaging Trauma Patients: A Narrative Review. J Clin Med. 2021;10(2):320. Published 2021 Jan 17. doi:10.3390/jcm10020320en_US
dc.identifier.urihttps://hdl.handle.net/1805/28931
dc.language.isoen_USen_US
dc.publisherMDPIen_US
dc.relation.isversionof10.3390/jcm10020320en_US
dc.relation.journalJournal of Clinical Medicineen_US
dc.rightsAttribution 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.sourcePMCen_US
dc.subjectBlood transfusionen_US
dc.subjectBlood component transfusionen_US
dc.subjectExsanguinationen_US
dc.subjectFibrinogenen_US
dc.subjectHemostaticsen_US
dc.subjectThromboelastographyen_US
dc.titleWhole Blood, Fixed Ratio, or Goal-Directed Blood Component Therapy for the Initial Resuscitation of Severely Hemorrhaging Trauma Patients: A Narrative Reviewen_US
dc.typeArticleen_US
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