Adoptive Transfer of Myeloid-Derived Suppressor Cells and T Cells in a Prostate Cancer Model
| dc.contributor.author | Yan, Libo | |
| dc.contributor.author | Xu, Yan | |
| dc.contributor.department | Department of Obstetrics and Gynecology, IU School of Medicine | en_US |
| dc.date.accessioned | 2017-06-06T19:13:17Z | |
| dc.date.available | 2017-06-06T19:13:17Z | |
| dc.date.issued | 2015-08-20 | |
| dc.description.abstract | The adoptive transfer of immune cells for cancer, chronic infection, and autoimmunity is an emerging field that has shown promise in recent trials. The transgenic adenocarcinoma mouse prostate (TRAMP) is a classical mouse model of prostate cancer (PCa) and TRAMP cell lines were derived from a TRAMP mouse tumor. TRAMP-C2 is tumorigenic when subcutaneously (s.c.) grafted into syngeneic C57BL/6 host mice (Foster et al., 1997). This protocol will describe the adoptive transfer of purified CD11b(+)Gr1(+) double positive (DP) myeloid-derived suppressor cells (MDSC) and CD3(+) T cells in the TRAMP-C2 prostate cancer mouse model in order to establish the intrinsic functionality of these immune cells and to determine their role in tumorigenesis in vivo (Yan et al., 2014). | en_US |
| dc.eprint.version | Author's manuscript | en_US |
| dc.identifier.citation | Yan, L., & Xu, Y. (2015). Adoptive Transfer of Myeloid-Derived Suppressor Cells and T Cells in a Prostate Cancer Model. Bio-Protocol, 5(16), e1557. | en_US |
| dc.identifier.uri | https://hdl.handle.net/1805/12865 | |
| dc.language.iso | en_US | en_US |
| dc.publisher | Bio-protocol LLC | en_US |
| dc.relation.journal | Bio-Protocol | en_US |
| dc.rights | Publisher Policy | en_US |
| dc.source | PMC | en_US |
| dc.subject | Cell transfer therapy | en_US |
| dc.subject | immunology | en_US |
| dc.subject | Prostate Cancer | en_US |
| dc.title | Adoptive Transfer of Myeloid-Derived Suppressor Cells and T Cells in a Prostate Cancer Model | en_US |
| dc.type | Article | en_US |