Photoinduced Pyridine N-oxides Catalyzed Carbon Radical Generation from Alkylboronic Acids

Abstract

Herein we report a protocol for the generation of alkyl carbon radicals from alkylboronic acids wherein photoexcited 4-nitropyridine N-oxide biradical features a catalyst to promote the nucleo-homolytic substitution of boronic acids. With a wide range of readily available aliphatic boronic acids, including methyl boronic acid, the developed catalytic system demonstrates broad applicability for alkylation, amination, and cyanation.