Mapping Cutaneous Field Carcinogenesis of Nonmelanoma Skin Cancer Using Mesoscopic Imaging of Pro-inflammation Cues

dc.contributor.authorShugar, Andrea L.
dc.contributor.authorKonger, Raymond L.
dc.contributor.authorRohan, Craig A.
dc.contributor.authorTravers, Jeffrey B.
dc.contributor.authorKim, Young L.
dc.contributor.departmentPathology and Laboratory Medicine, School of Medicine
dc.date.accessioned2025-05-20T11:31:12Z
dc.date.available2025-05-20T11:31:12Z
dc.date.issued2024
dc.description.abstractNonmelanoma skin cancers remain the most widely diagnosed types of cancers globally. Thus, for optimal patient management, it has become imperative that we focus our efforts on the detection and monitoring of cutaneous field carcinogenesis. The concept of field cancerization (or field carcinogenesis), introduced by Slaughter in 1953 in the context of oral cancer, suggests that invasive cancer may emerge from a molecularly and genetically altered field affecting a substantial area of underlying tissue including the skin. A carcinogenic field alteration, present in precancerous tissue over a relatively large area, is not easily detected by routine visualization. Conventional dermoscopy and microscopy imaging are often limited in assessing the entire carcinogenic landscape. Recent efforts have suggested the use of noninvasive mesoscopic (between microscopic and macroscopic) optical imaging methods that can detect chronic inflammatory features to identify pre-cancerous and cancerous angiogenic changes in tissue microenvironments. This concise review covers major types of mesoscopic optical imaging modalities capable of assessing pro-inflammatory cues by quantifying blood haemoglobin parameters and hemodynamics. Importantly, these imaging modalities demonstrate the ability to detect angiogenesis and inflammation associated with actinically damaged skin. Representative experimental preclinical and human clinical studies using these imaging methods provide biological and clinical relevance to cutaneous field carcinogenesis in altered tissue microenvironments in the apparently normal epidermis and dermis. Overall, mesoscopic optical imaging modalities assessing chronic inflammatory hyperemia can enhance the understanding of cutaneous field carcinogenesis, offer a window of intervention and monitoring for actinic keratoses and nonmelanoma skin cancers and maximise currently available treatment options.
dc.eprint.versionAuthor's manuscript
dc.identifier.citationShugar AL, Konger RL, Rohan CA, Travers JB, Kim YL. Mapping cutaneous field carcinogenesis of nonmelanoma skin cancer using mesoscopic imaging of pro-inflammation cues. Exp Dermatol. 2024;33(4):e15076. doi:10.1111/exd.15076
dc.identifier.urihttps://hdl.handle.net/1805/48266
dc.language.isoen_US
dc.publisherWiley
dc.relation.isversionof10.1111/exd.15076
dc.relation.journalExperimental Dermatology
dc.rightsPublisher Policy
dc.sourcePMC
dc.subjectHyperemia
dc.subjectInflammation
dc.subjectOptical imaging
dc.subjectSkin neoplasms
dc.titleMapping Cutaneous Field Carcinogenesis of Nonmelanoma Skin Cancer Using Mesoscopic Imaging of Pro-inflammation Cues
dc.typeArticle
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