An Epidemic Zika Virus Isolate Drives Enhanced T Follicular Helper Cell and B Cell-Mediated Immunity
dc.contributor.author | Pardy, Ryan D. | |
dc.contributor.author | Gentile, Maria E. | |
dc.contributor.author | Carter, Alexandria M. | |
dc.contributor.author | Condotta, Stephanie A. | |
dc.contributor.author | King, Irah L. | |
dc.contributor.author | Richer, Martin J. | |
dc.contributor.department | Microbiology and Immunology, School of Medicine | |
dc.date.accessioned | 2023-12-05T10:40:23Z | |
dc.date.available | 2023-12-05T10:40:23Z | |
dc.date.issued | 2022 | |
dc.description.abstract | Zika virus (ZIKV) is a mosquito-borne pathogen that recently caused a series of increasingly severe outbreaks. We previously demonstrated that, compared with a pre-epidemic isolate (ZIKVCDN), a Brazilian ZIKV isolate (ZIKVBR) possesses a novel capacity to suppress host immunity, resulting in delayed viral clearance. However, whether ZIKVBR modulates CD4 T cell responses remains unknown. In this study, we show that, in comparison with ZIKVCDN infection, CD4 T cells are less polarized to the Th1 subtype following ZIKVBR challenge in mice. In contrast, we observed an enhanced accumulation of T follicular helper cells 10, 14, and 21 d postinfection with ZIKVBR This response correlated with an enhanced germinal center B cell response and robust production of higher avidity-neutralizing Abs following ZIKVBR infection. Taken together, our data suggest that contemporary ZIKV strains have evolved to differentially induce CD4 T cell, B cell, and Ab responses and this could provide a model to further define the signals required for T follicular helper cell development. | |
dc.eprint.version | Author's manuscript | |
dc.identifier.citation | Pardy RD, Gentile ME, Carter AM, Condotta SA, King IL, Richer MJ. An Epidemic Zika Virus Isolate Drives Enhanced T Follicular Helper Cell and B Cell-Mediated Immunity. J Immunol. 2022;208(7):1719-1728. doi:10.4049/jimmunol.2100049 | |
dc.identifier.uri | https://hdl.handle.net/1805/37287 | |
dc.language.iso | en_US | |
dc.publisher | The American Association of Immunologists | |
dc.relation.isversionof | 10.4049/jimmunol.2100049 | |
dc.relation.journal | The Journal of Immunology | |
dc.rights | Publisher Policy | |
dc.source | PMC | |
dc.subject | B-Lymphocytes | |
dc.subject | T Follicular Helper Cells | |
dc.subject | Zika Virus Infection | |
dc.title | An Epidemic Zika Virus Isolate Drives Enhanced T Follicular Helper Cell and B Cell-Mediated Immunity | |
dc.type | Article |