Of balls, inks and cages: Hybrid biofabrication of 3D tissue analogs
dc.contributor.author | Moldovan, Nicanor I. | |
dc.contributor.author | Moldovan, Leni | |
dc.contributor.author | Raghunath, Michael | |
dc.contributor.department | Biomedical Engineering, School of Engineering and Technology | en_US |
dc.date.accessioned | 2019-11-15T20:01:04Z | |
dc.date.available | 2019-11-15T20:01:04Z | |
dc.date.issued | 2019 | |
dc.description.abstract | The overarching principle of three-dimensional (3D) bioprinting is the placing of cells or cell clusters in the 3D space to generate a cohesive tissue microarchitecture that comes close to in vivo characteristics. To achieve this goal, several technical solutions are available, generating considerable combinatorial bandwidth: (i) Support structures are generated first, and cells are seeded subsequently; (ii) alternatively, cells are delivered in a printing medium, so-called “bioink,” that contains them during the printing process and ensures shape fidelity of the generated structure; and (iii) a “scaffold-free” version of bioprinting, where only cells are used and the extracellular matrix is produced by the cells themselves, also recently entered a phase of accelerated development and successful applications. However, the scaffold-free approaches may still benefit from secondary incorporation of scaffolding materials, thus expanding their versatility. Reversibly, the bioink-based bioprinting could also be improved by adopting some of the principles and practices of scaffold-free biofabrication. Collectively, we anticipate that combinations of these complementary methods in a “hybrid” approach, rather than their development in separate technological niches, will largely increase their efficiency and applicability in tissue engineering. | en_US |
dc.eprint.version | Final published version | en_US |
dc.identifier.citation | Moldovan, N., Maldovan, L., & Raghunath, M. (2019). Of balls, inks and cages: Hybrid biofabrication of 3D tissue analogs. International Journal of Bioprinting, 5(1). http://dx.doi.org/10.18063/ijb.v5i1.167 | en_US |
dc.identifier.uri | https://hdl.handle.net/1805/21354 | |
dc.language.iso | en | en_US |
dc.relation.isversionof | 10.18063/ijb.v5i1.167 | en_US |
dc.relation.journal | International Journal of Bioprinting | en_US |
dc.rights | Attribution-NonCommercial 3.0 United States | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc/3.0/us/ | * |
dc.source | Publisher | en_US |
dc.subject | tissue engineering | en_US |
dc.subject | scaffolds | en_US |
dc.subject | bioprinting | en_US |
dc.title | Of balls, inks and cages: Hybrid biofabrication of 3D tissue analogs | en_US |
dc.type | Article | en_US |