Application of the Milan System for Reporting Salivary Gland Cytopathology: A Retrospective 12-Year Bi-institutional Study
dc.contributor.author | Wu, Howard H. | |
dc.contributor.author | Alruwaii, Fatimah | |
dc.contributor.author | Zeng, Bao-Rung | |
dc.contributor.author | Cramer, Harvey M. | |
dc.contributor.author | Lai, Chiung-Ru | |
dc.contributor.author | Hang, Jen-Fan | |
dc.contributor.department | Pathology and Laboratory Medicine, School of Medicine | en_US |
dc.date.accessioned | 2020-08-12T19:59:08Z | |
dc.date.available | 2020-08-12T19:59:08Z | |
dc.date.issued | 2019-06 | |
dc.description.abstract | Objectives Multi-institutional studies are required for the validation of the Milan System for Reporting Salivary Gland Cytopathology (MSRSGC). Methods A total of 1,560 fine-needle aspirations of the salivary glands were retrieved from two institutions for a 12-year period. The diagnoses were reclassified based on the MSRSGC. Risk of malignancy (ROM) for each category was calculated based on 694 histologic follow-up cases. Results The ROM for each category was: 18.3% for nondiagnostic, 8.9% for nonneoplastic, 37.5% for atypia of undetermined significance (AUS), 2.9% for benign neoplasm, 40.7% for salivary gland neoplasm of uncertain malignant potential (SUMP), 100% for suspicious for malignancy, and 98.3% for malignant. The sensitivity, specificity, positive predictive rate, and negative predictive rates were 89%, 99%, 98%, and 96%, respectively. Conclusions The results of the current study are in keeping with the MSRSGC. The indeterminate categories of AUS and SUMP showed intermediate ROMs at 37.5% and 40.7%, respectively. | en_US |
dc.eprint.version | Author's manuscript | en_US |
dc.identifier.citation | Wu, H. H., Alruwaii, F., Zeng, B.-R., Cramer, H. M., Lai, C.-R., & Hang, J.-F. (2019). Application of the Milan System for Reporting Salivary Gland Cytopathology: A Retrospective 12-Year Bi-institutional Study. American Journal of Clinical Pathology, 151(6), 613–621. https://doi.org/10.1093/ajcp/aqz006 | en_US |
dc.identifier.uri | https://hdl.handle.net/1805/23594 | |
dc.language.iso | en | en_US |
dc.publisher | Oxford | en_US |
dc.relation.isversionof | 10.1093/ajcp/aqz006 | en_US |
dc.relation.journal | American Journal of Clinical Pathology | en_US |
dc.rights | Publisher Policy | en_US |
dc.source | Author | en_US |
dc.subject | fine‐needle aspiration | en_US |
dc.subject | Milan System for Reporting Salivary Gland Cytopathology | en_US |
dc.subject | salivary glands | en_US |
dc.title | Application of the Milan System for Reporting Salivary Gland Cytopathology: A Retrospective 12-Year Bi-institutional Study | en_US |
dc.type | Article | en_US |