Salicylate administration suppresses the inflammatory response to nutrients and improves ovarian function in polycystic ovary syndrome
dc.contributor.author | González, Frank | |
dc.contributor.author | Mather, Kieren J. | |
dc.contributor.author | Considine, Robert V. | |
dc.contributor.author | Abdelhadi, Ola A. | |
dc.contributor.author | Acton, Anthony J. | |
dc.contributor.department | Medicine, School of Medicine | en_US |
dc.date.accessioned | 2023-03-16T13:23:27Z | |
dc.date.available | 2023-03-16T13:23:27Z | |
dc.date.issued | 2020-10 | |
dc.description.abstract | Oxidative stress (OS) and inflammation are often present in polycystic ovary syndrome (PCOS). We examined the effects of salsalate treatment on nutrient-induced OS and inflammation, ovarian androgen secretion, ovulation, and insulin sensitivity in PCOS. Eight lean insulin-sensitive women with PCOS and eight age- and body composition-matched ovulatory controls for baseline comparison participated in the study. The women with PCOS underwent a 12-wk treatment of salsalate, a nonsteroidal anti-inflammatory drug, at a dose of 3 g daily. Markers of OS and inflammation were quantified in mononuclear cells (MNC) and plasma from blood drawn fasting and 2 h after saturated fat ingestion before and after treatment. Ovarian androgen secretion was assessed from blood drawn fasting and 24, 48, and 72 h after human chorionic gonadotropin (HCG) administration before and after treatment. Ovulation was documented based on biphasic basal body temperatures and luteal range progesterone elevations. A two-step pancreatic clamp was performed pre- and posttreatment to measure basal endogenous glucose production (EGP) and the steady-state glucose disposal rate (GDR) during the euglycemic phase and markers of OS and inflammation in MNC and plasma during the hyperglycemic phase. Salsalate administration suppressed lipid- and glucose-stimulated reactive oxygen species generation, activated nuclear factor-κB and circulating tumor necrosis factor-α, normalized basal androgen levels, and lowered HCG-stimulated androgen secretion without altering EGP or GDR. Four salsalate-treated subjects responded with two consecutive ovulations. We conclude that in PCOS, salsalate-induced suppression of OS and inflammation ameliorates ovarian androgen hypersecretion and may induce ovulation while maintaining insulin action. | en_US |
dc.identifier.citation | González F, Mather KJ, Considine RV, Abdelhadi OA, Acton AJ. Salicylate administration suppresses the inflammatory response to nutrients and improves ovarian function in polycystic ovary syndrome. Am J Physiol Endocrinol Metab. 2020;319(4):E744-E752. doi:10.1152/ajpendo.00228.2020 | en_US |
dc.identifier.uri | https://hdl.handle.net/1805/31941 | |
dc.language.iso | en_US | en_US |
dc.publisher | American Physiological Society | en_US |
dc.relation.isversionof | 10.1152/ajpendo.00228.2020 | en_US |
dc.relation.journal | American Journal of Physiology: Endocrinology and Metabolism | en_US |
dc.rights | Publisher Policy | en_US |
dc.source | PMC | en_US |
dc.subject | Inflammation | en_US |
dc.subject | Nutrients | en_US |
dc.subject | Ovarian hyperandrogenism | en_US |
dc.subject | Oxidative stress | en_US |
dc.subject | Polycystic ovary syndrome | en_US |
dc.subject | Salicylates | en_US |
dc.title | Salicylate administration suppresses the inflammatory response to nutrients and improves ovarian function in polycystic ovary syndrome | en_US |
dc.type | Article | en_US |
ul.alternative.fulltext | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7750514/ | en_US |
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