Salicylate administration suppresses the inflammatory response to nutrients and improves ovarian function in polycystic ovary syndrome

dc.contributor.authorGonzález, Frank
dc.contributor.authorMather, Kieren J.
dc.contributor.authorConsidine, Robert V.
dc.contributor.authorAbdelhadi, Ola A.
dc.contributor.authorActon, Anthony J.
dc.contributor.departmentMedicine, School of Medicineen_US
dc.date.accessioned2023-03-16T13:23:27Z
dc.date.available2023-03-16T13:23:27Z
dc.date.issued2020-10
dc.description.abstractOxidative stress (OS) and inflammation are often present in polycystic ovary syndrome (PCOS). We examined the effects of salsalate treatment on nutrient-induced OS and inflammation, ovarian androgen secretion, ovulation, and insulin sensitivity in PCOS. Eight lean insulin-sensitive women with PCOS and eight age- and body composition-matched ovulatory controls for baseline comparison participated in the study. The women with PCOS underwent a 12-wk treatment of salsalate, a nonsteroidal anti-inflammatory drug, at a dose of 3 g daily. Markers of OS and inflammation were quantified in mononuclear cells (MNC) and plasma from blood drawn fasting and 2 h after saturated fat ingestion before and after treatment. Ovarian androgen secretion was assessed from blood drawn fasting and 24, 48, and 72 h after human chorionic gonadotropin (HCG) administration before and after treatment. Ovulation was documented based on biphasic basal body temperatures and luteal range progesterone elevations. A two-step pancreatic clamp was performed pre- and posttreatment to measure basal endogenous glucose production (EGP) and the steady-state glucose disposal rate (GDR) during the euglycemic phase and markers of OS and inflammation in MNC and plasma during the hyperglycemic phase. Salsalate administration suppressed lipid- and glucose-stimulated reactive oxygen species generation, activated nuclear factor-κB and circulating tumor necrosis factor-α, normalized basal androgen levels, and lowered HCG-stimulated androgen secretion without altering EGP or GDR. Four salsalate-treated subjects responded with two consecutive ovulations. We conclude that in PCOS, salsalate-induced suppression of OS and inflammation ameliorates ovarian androgen hypersecretion and may induce ovulation while maintaining insulin action.en_US
dc.identifier.citationGonzález F, Mather KJ, Considine RV, Abdelhadi OA, Acton AJ. Salicylate administration suppresses the inflammatory response to nutrients and improves ovarian function in polycystic ovary syndrome. Am J Physiol Endocrinol Metab. 2020;319(4):E744-E752. doi:10.1152/ajpendo.00228.2020en_US
dc.identifier.urihttps://hdl.handle.net/1805/31941
dc.language.isoen_USen_US
dc.publisherAmerican Physiological Societyen_US
dc.relation.isversionof10.1152/ajpendo.00228.2020en_US
dc.relation.journalAmerican Journal of Physiology: Endocrinology and Metabolismen_US
dc.rightsPublisher Policyen_US
dc.sourcePMCen_US
dc.subjectInflammationen_US
dc.subjectNutrientsen_US
dc.subjectOvarian hyperandrogenismen_US
dc.subjectOxidative stressen_US
dc.subjectPolycystic ovary syndromeen_US
dc.subjectSalicylatesen_US
dc.titleSalicylate administration suppresses the inflammatory response to nutrients and improves ovarian function in polycystic ovary syndromeen_US
dc.typeArticleen_US
ul.alternative.fulltexthttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7750514/en_US
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