Cerebrospinal fluid biomarkers in the Longitudinal Early-onset Alzheimer's Disease Study

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dc.contributor.authorDage, Jeffrey L.
dc.contributor.authorEloyan, Ani
dc.contributor.authorThangarajah, Maryanne
dc.contributor.authorHammers, Dustin B.
dc.contributor.authorFagan, Anne M.
dc.contributor.authorGray, Julia D.
dc.contributor.authorSchindler, Suzanne E.
dc.contributor.authorSnoddy, Casey
dc.contributor.authorNudelman, Kelly N. H.
dc.contributor.authorFaber, Kelley M.
dc.contributor.authorForoud, Tatiana
dc.contributor.authorAisen, Paul
dc.contributor.authorGriffin, Percy
dc.contributor.authorGrinberg, Lea T.
dc.contributor.authorIaccarino, Leonardo
dc.contributor.authorKirby, Kala
dc.contributor.authorKramer, Joel
dc.contributor.authorKoeppe, Robert
dc.contributor.authorKukull, Walter A.
dc.contributor.authorLa Joie, Renaud
dc.contributor.authorMundada, Nidhi S.
dc.contributor.authorMurray, Melissa E.
dc.contributor.authorRumbaugh, Malia
dc.contributor.authorSoleimani-Meigooni, David N.
dc.contributor.authorToga, Arthur W.
dc.contributor.authorTouroutoglou, Alexandra
dc.contributor.authorVemuri, Prashanthi
dc.contributor.authorAtri, Alireza
dc.contributor.authorBeckett, Laurel A.
dc.contributor.authorDay, Gregory S.
dc.contributor.authorGraff-Radford, Neill R.
dc.contributor.authorDuara, Ranjan
dc.contributor.authorHonig, Lawrence S.
dc.contributor.authorJones, David T.
dc.contributor.authorMasdeu, Joseph C.
dc.contributor.authorMendez, Mario F.
dc.contributor.authorMusiek, Erik
dc.contributor.authorOnyike, Chiadi U.
dc.contributor.authorRiddle, Meghan
dc.contributor.authorRogalski, Emily
dc.contributor.authorSalloway, Stephen
dc.contributor.authorSha, Sharon J.
dc.contributor.authorTurner, Raymond S.
dc.contributor.authorWingo, Thomas S.
dc.contributor.authorWolk, David A.
dc.contributor.authorWomack, Kyle B.
dc.contributor.authorCarrillo, Maria C.
dc.contributor.authorDickerson, Bradford C.
dc.contributor.authorRabinovici, Gil D.
dc.contributor.authorApostolova, Liana G.
dc.contributor.authorLEADS Consortium
dc.contributor.departmentNeurology, School of Medicine
dc.date.accessioned2024-12-12T11:46:55Z
dc.date.available2024-12-12T11:46:55Z
dc.date.issued2023
dc.description.abstractIntroduction: One goal of the Longitudinal Early Onset Alzheimer's Disease Study (LEADS) is to define the fluid biomarker characteristics of early-onset Alzheimer's disease (EOAD). Methods: Cerebrospinal fluid (CSF) concentrations of Aβ1-40, Aβ1-42, total tau (tTau), pTau181, VILIP-1, SNAP-25, neurogranin (Ng), neurofilament light chain (NfL), and YKL-40 were measured by immunoassay in 165 LEADS participants. The associations of biomarker concentrations with diagnostic group and standard cognitive tests were evaluated. Results: Biomarkers were correlated with one another. Levels of CSF Aβ42/40, pTau181, tTau, SNAP-25, and Ng in EOAD differed significantly from cognitively normal and early-onset non-AD dementia; NfL, YKL-40, and VILIP-1 did not. Across groups, all biomarkers except SNAP-25 were correlated with cognition. Within the EOAD group, Aβ42/40, NfL, Ng, and SNAP-25 were correlated with at least one cognitive measure. Discussion: This study provides a comprehensive analysis of CSF biomarkers in sporadic EOAD that can inform EOAD clinical trial design.
dc.eprint.versionAuthor's manuscript
dc.identifier.citationDage JL, Eloyan A, Thangarajah M, et al. Cerebrospinal fluid biomarkers in the Longitudinal Early-onset Alzheimer's Disease Study. Alzheimers Dement. 2023;19 Suppl 9(Suppl 9):S115-S125. doi:10.1002/alz.13399
dc.identifier.urihttps://hdl.handle.net/1805/44967
dc.language.isoen_US
dc.publisherWiley
dc.relation.isversionof10.1002/alz.13399
dc.relation.journalAlzheimer’s & Dementia
dc.rightsPublisher Policy
dc.sourcePMC
dc.subjectAlzheimer's disease
dc.subjectAβ42/40
dc.subjectCSF
dc.subjectNfL
dc.subjectSNAP-25
dc.subjectVILIP-1
dc.subjectYKL-40
dc.subjectAmyloid
dc.subjectAstrogliosis
dc.subjectBiomarkers
dc.subjectDementia
dc.subjectNeurogranin
dc.subjectpTau181
dc.subjecttTau
dc.subjectTau
dc.titleCerebrospinal fluid biomarkers in the Longitudinal Early-onset Alzheimer's Disease Study
dc.typeArticle
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