EMF Antenna Exposure on a Multilayer Human Head Simulation for Alzheimer Disease Treatments

dc.contributor.authorPerez, Felipe P.
dc.contributor.authorRahmani, Maryam
dc.contributor.authorEmberson, John
dc.contributor.authorWeber, Makenzie
dc.contributor.authorMorisaki, Jorge
dc.contributor.authorAmran, Farhan
dc.contributor.authorBakri, Syazwani
dc.contributor.authorHalim, Akmal
dc.contributor.authorDsouza, Alston
dc.contributor.authorYusuff, Nurafifi Mohd
dc.contributor.authorFarhan, Amran
dc.contributor.authorMaulucci, James
dc.contributor.authorRizkalla, Maher
dc.contributor.departmentMedicine, School of Medicineen_US
dc.date.accessioned2023-07-12T11:43:11Z
dc.date.available2023-07-12T11:43:11Z
dc.date.issued2022
dc.description.abstractIn this paper, we follow up with our preliminary biological studies that showed that Repeated electromagnetic field stimulation (REMFS) decreased the toxic amyloid-beta (Aβ) levels, which is considered to be the cause of Alzheimer's disease (AD). The REMFS parameters of these exposures were a frequency of 64 MHz and a Specific absorption rate (SAR) of 0.4 to 0.9 W/Kg in primary human neuronal cultures. In this work, an electromagnetic field (EMF) model was simulated using high-frequency simulation system (HFSS/EMPro) software. Our goal was to achieve the EM parameters (EMF Frequency and SAR) required to decrease the toxic Aβ levels in our biological studies in a simulated human head. The simulations performed here will potentially lead to the successful development of an exposure system to treat Alzheimer's disease patients. A popular VFH (very high frequency) patch microstrip antenna system was considered in the study. The selection was based on simple and easy construction and appropriateness to the VHF applications. The evaluation of the SAR and temperature distribution on the various head layers, including skin, fat, dura, the cerebrospinal (CSF), and grey matter, brain tissues, were determined for efficacy SAR and safety temperature increase on a simulated human head. Based on a current pulse of 1 A peak current fed to the antenna feeder, a maximum SAR of 0.6 W/Kg was achieved. A range of 0.4 to 0.6 SAR was observed over the various layers of the simulated human head. The initial design of the antenna indicated an antenna size in the order of 1 m in length and width, suggesting a stationary practical model for AD therapy. Future direction is given for wearable antenna and exposure system, featuring high efficiency and patient comfort.en_US
dc.eprint.versionAuthor's manuscripten_US
dc.identifier.citationPerez FP, Rahmani M, Emberson J, et al. EMF Antenna Exposure on a Multilayer Human Head Simulation for Alzheimer Disease Treatments. J Biomed Sci Eng. 2022;15(5):129-139. doi:10.4236/jbise.2022.155013en_US
dc.identifier.urihttps://hdl.handle.net/1805/34302
dc.language.isoen_USen_US
dc.publisherScientific Researchen_US
dc.relation.isversionof10.4236/jbise.2022.155013en_US
dc.relation.journalJournal of Biomedical Science and Engineeringen_US
dc.rightsPublisher Policyen_US
dc.sourcePMCen_US
dc.subjectAntennaen_US
dc.subjectBrain tissuesen_US
dc.subjectSimulationen_US
dc.subjectAlzheimeren_US
dc.titleEMF Antenna Exposure on a Multilayer Human Head Simulation for Alzheimer Disease Treatmentsen_US
dc.typeArticleen_US
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