Splitting the chains: ultra-basal insulin analog uncovers a redox mechanism of hormone clearance

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dc.contributor.authorWeiss, Michael A.
dc.contributor.departmentBiochemistry and Molecular Biology, School of Medicine
dc.date.accessioned2024-12-09T15:10:54Z
dc.date.available2024-12-09T15:10:54Z
dc.date.issued2024-11-11
dc.description.abstractReporting in Nature Communications, Kjeldsen and colleagues describe a redox mechanism of insulin clearance based on separation of A- and B chains. Exploiting an ultra-long-acting analog protected from classical clearance pathways, the study highlights principles of protein stability in pharmacology.
dc.eprint.versionFinal published version
dc.identifier.citationWeiss MA. Splitting the chains: ultra-basal insulin analog uncovers a redox mechanism of hormone clearance. Nat Commun. 2024;15(1):9744. Published 2024 Nov 11. doi:10.1038/s41467-024-54006-6
dc.identifier.urihttps://hdl.handle.net/1805/44847
dc.language.isoen_US
dc.publisherSpringer Nature
dc.relation.isversionof10.1038/s41467-024-54006-6
dc.relation.journalNature Communications
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internationalen
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0
dc.sourcePMC
dc.subjectInsulin
dc.subjectProtein stability
dc.subjectPharmacology
dc.titleSplitting the chains: ultra-basal insulin analog uncovers a redox mechanism of hormone clearance
dc.typeArticle
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