Identification of N-benzyltetrahydroisoquinolines as novel anti-neuroinflammatory agents
| dc.contributor.author | Gabet, Brian | |
| dc.contributor.author | Kuo, Ping-Chang | |
| dc.contributor.author | Fuentes, Steven | |
| dc.contributor.author | Patel, Yamini | |
| dc.contributor.author | Adow, Ahmed | |
| dc.contributor.author | Alsakka, Mary | |
| dc.contributor.author | Avila, Paula | |
| dc.contributor.author | Beam, Teri | |
| dc.contributor.author | Yen, Jui-Hung | |
| dc.contributor.author | Brown, Dennis A. | |
| dc.contributor.department | Medicine, School of Medicine | en_US |
| dc.date.accessioned | 2018-11-20T18:00:47Z | |
| dc.date.available | 2018-11-20T18:00:47Z | |
| dc.date.issued | 2018-11 | |
| dc.description.abstract | A series of simplified berberine analogs was designed, synthesized, and evaluated for anti-inflammatory activity. SAR studies identified N-benzyltetrahydroisoquinoline 7d as a potent berberine analog. 7d suppressed LPS-induced inflammatory cytokine levels in both BV2 cells and primary microglia. Taken together, our results suggest that simplified BB analogs have therapeutic potential as a novel class of anti-neuroinflammatory agents. | en_US |
| dc.eprint.version | Author's manuscript | en_US |
| dc.identifier.citation | Gabet, B., Kuo, P.-C., Fuentes, S., Patel, Y., Adow, A., Alsakka, M., … Brown, D. A. (2018). Identification of N-benzyltetrahydroisoquinolines as novel anti-neuroinflammatory agents. Bioorganic & Medicinal Chemistry. https://doi.org/10.1016/j.bmc.2018.10.020 | en_US |
| dc.identifier.uri | https://hdl.handle.net/1805/17797 | |
| dc.language.iso | en | en_US |
| dc.publisher | Elsevier | en_US |
| dc.relation.isversionof | 10.1016/j.bmc.2018.10.020 | en_US |
| dc.relation.journal | Bioorganic & Medicinal Chemistry | en_US |
| dc.rights | Publisher Policy | en_US |
| dc.source | Author | en_US |
| dc.subject | berberine | en_US |
| dc.subject | neuroinflammation | en_US |
| dc.subject | multiple sclerosis | en_US |
| dc.title | Identification of N-benzyltetrahydroisoquinolines as novel anti-neuroinflammatory agents | en_US |
| dc.type | Article | en_US |