Common genetic variants influence human subcortical brain structures

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dc.contributor.authorHibar, Derrek P.
dc.contributor.authorStein, Jason L.
dc.contributor.authorRenteria, Miguel E.
dc.contributor.authorArias-Vasquez, Alejandro
dc.contributor.authorDesrivières, Sylvane
dc.contributor.authorJahanshad, Neda
dc.contributor.authorToro, Roberto
dc.contributor.authorWittfeld, Katharina
dc.contributor.authorAbramovic, Lucija
dc.contributor.authorAndersson, Micael
dc.contributor.authorAribisala, Benjamin S.
dc.contributor.authorArmstrong, Nicola J.
dc.contributor.authorBernard, Manon
dc.contributor.authorBohlken, Marc M.
dc.contributor.authorBoks, Marco P.
dc.contributor.authorBralten, Janita
dc.contributor.authorBrown, Andrew A.
dc.contributor.authorChakravarty, M. Mallar
dc.contributor.authorChen, Qiang
dc.contributor.authorChing, Christopher R. K.
dc.contributor.authorCuellar-Partida, Gabriel
dc.contributor.authorden Braber, Anouk
dc.contributor.authorGiddaluru, Sudheer
dc.contributor.authorGoldman, Aaron L.
dc.contributor.authorGrimm, Oliver
dc.contributor.authorGuadalupe, Tulio
dc.contributor.authorHass, Johanna
dc.contributor.authorWoldehawariat, Girma
dc.contributor.authorHolmes, Avram J.
dc.contributor.authorHoogman, Martine
dc.contributor.authorJanowitz, Deborah
dc.contributor.authorJia, Tianye
dc.contributor.authorKim, Sungeun
dc.contributor.authorKlein, Marieke
dc.contributor.authorKraemer, Bernd
dc.contributor.authorLee, Phil H.
dc.contributor.authorOlde Loohuis, Loes M.
dc.contributor.authorLuciano, Michelle
dc.contributor.authorMacare, Christine
dc.contributor.authorMather, Karen A.
dc.contributor.authorMattheisen, Manuel
dc.contributor.authorMilaneschi, Yuri
dc.contributor.authorNho, Kwangsik
dc.contributor.authorPapmeyer, Martina
dc.contributor.authorRamasamy, Adaikalavan
dc.contributor.authorRisacher, Shannon L.
dc.contributor.authorRoiz-Santiañez, Roberto
dc.contributor.authorRose, Emma J.
dc.contributor.authorSalami, Alireza
dc.contributor.authorSämann, Philipp G.
dc.contributor.authorSchmaal, Lianne
dc.contributor.authorSchork, Andrew J.
dc.contributor.authorShin, Jean
dc.contributor.authorStrike, Lachlan T.
dc.contributor.authorTeumer, Alexander
dc.contributor.authorvan Donkelaar, Marjolein M. J.
dc.contributor.authorvan Eijk, Kristel R.
dc.contributor.authorWalters, Raymond K.
dc.contributor.authorWestlye, Lars T.
dc.contributor.authorWhelan, Christopher D.
dc.contributor.authorWinkler, Anderson M.
dc.contributor.authorZwiers, Marcel P.
dc.contributor.authorAlhusaini, Saud
dc.contributor.authorAthanasiu, Lavinia
dc.contributor.authorEhrlich, Stefan
dc.contributor.authorHakobjan, Marina M. H.
dc.contributor.authorHartberg, Cecilie B.
dc.contributor.authorHaukvik, Unn K.
dc.contributor.authorHeister, Angelien J. G. A. M.
dc.contributor.authorHoehn, David
dc.contributor.authorKasperaviciute, Dalia
dc.contributor.authorLiewald, David C. M.
dc.contributor.authorLopez, Lorna M.
dc.contributor.authorMakkinje, Remco R. R.
dc.contributor.authorMatarin, Mar
dc.contributor.authorNaber, Marlies A. M.
dc.contributor.authorMcKay, D. Reese
dc.contributor.authorNeedham, Margaret
dc.contributor.authorNugent, Allison C.
dc.contributor.authorPütz, Benno
dc.contributor.authorRoyle, Natalie A.
dc.contributor.authorShen, Li
dc.contributor.authorSprooten, Emma
dc.contributor.authorTrabzuni, Daniah
dc.contributor.authorvan der Marel, Saskia S. L.
dc.contributor.authorvan Hulzen, Kimm J. E.
dc.contributor.authorWalton, Esther
dc.contributor.authorWolf, Christiane
dc.contributor.authorAlmasy, Laura
dc.contributor.authorAmes, David
dc.contributor.authorArepalli, Sampath
dc.contributor.authorAssareh, Amelia A.
dc.contributor.authorBastin, Mark E.
dc.contributor.authorBrodaty, Henry
dc.contributor.authorBulayeva, Kazima B.
dc.contributor.authorCarless, Melanie A.
dc.contributor.authorCichon, Sven
dc.contributor.authorCorvin, Aiden
dc.contributor.authorCurran, Joanne E.
dc.contributor.authorCzisch, Michael
dc.contributor.authorde Zubicaray, Greig I.
dc.contributor.authorDillman, Allissa
dc.contributor.authorDuggirala, Ravi
dc.contributor.authorDyer, Thomas D.
dc.contributor.authorErk, Susanne
dc.contributor.authorFedko, Iryna O.
dc.contributor.authorFerrucci, Luigi
dc.contributor.authorForoud, Tatiana M.
dc.contributor.authorFox, Peter T.
dc.contributor.authorFukunaga, Masaki
dc.contributor.authorGibbs, J. Raphael
dc.contributor.authorGöring, Harald H. H.
dc.contributor.authorGreen, Robert C.
dc.contributor.authorGuelfi, Sebastian
dc.contributor.authorHansell, Narelle K.
dc.contributor.authorHartman, Catharina A.
dc.contributor.authorHegenscheid, Katrin
dc.contributor.authorHeinz, Andreas
dc.contributor.authorHernandez, Dena G.
dc.contributor.authorHeslenfeld, Dirk J.
dc.contributor.authorHoekstra, Pieter J.
dc.contributor.authorHolsboer, Florian
dc.contributor.authorHomuth, Georg
dc.contributor.authorHottenga, Jouke-Jan
dc.contributor.authorIkeda, Masashi
dc.contributor.authorJack, Clifford R.
dc.contributor.authorJenkinson, Mark
dc.contributor.authorJohnson, Robert
dc.contributor.authorKanai, Ryota
dc.contributor.authorKeil, Maria
dc.contributor.authorKent, Jack W.
dc.contributor.authorKochunov, Peter
dc.contributor.authorKwok, John B.
dc.contributor.authorLawrie, Stephen M.
dc.contributor.authorLiu, Xinmin
dc.contributor.authorLongo, Dan L.
dc.contributor.authorMcMahon, Katie L.
dc.contributor.authorMeisenzahl, Eva
dc.contributor.authorMelle, Ingrid
dc.contributor.authorMohnke, Sebastian
dc.contributor.authorMontgomery, Grant W.
dc.contributor.authorMostert, Jeanette C.
dc.contributor.authorMühleisen, Thomas W.
dc.contributor.authorNalls, Michael A.
dc.contributor.authorNichols, Thomas E.
dc.contributor.authorNilsson, Lars G.
dc.contributor.authorNöthen, Markus M.
dc.contributor.authorOhi, Kazutaka
dc.contributor.authorOlvera, Rene L.
dc.contributor.authorPerez-Iglesias, Rocio
dc.contributor.authorPike, G. Bruce
dc.contributor.authorPotkin, Steven G.
dc.contributor.authorReinvang, Ivar
dc.contributor.authorReppermund, Simone
dc.contributor.authorRietschel, Marcella
dc.contributor.authorRomanczuk-Seiferth, Nina
dc.contributor.authorRosen, Glenn D.
dc.contributor.authorRujescu, Dan
dc.contributor.authorSchnell, Knut
dc.contributor.authorSchofield, Peter R.
dc.contributor.authorSmith, Colin
dc.contributor.authorSteen, Vidar M.
dc.contributor.authorSussmann, Jessika E.
dc.contributor.authorThalamuthu, Anbupalam
dc.contributor.authorToga, Arthur W.
dc.contributor.authorTraynor, Bryan J.
dc.contributor.authorTroncoso, Juan
dc.contributor.authorTurner, Jessica A.
dc.contributor.authorValdés Hernández, Maria C.
dc.contributor.authorvan ’t Ent, Dennis
dc.contributor.authorvan der Brug, Marcel
dc.contributor.authorvan der Wee, Nic J. A.
dc.contributor.authorvan Tol, Marie-Jose
dc.contributor.authorVeltman, Dick J.
dc.contributor.authorWassink, Thomas H.
dc.contributor.authorWestman, Eric
dc.contributor.authorZielke, Ronald H.
dc.contributor.authorZonderman, Alan B.
dc.contributor.authorAshbrook, David G.
dc.contributor.authorHager, Reinmar
dc.contributor.authorLu, Lu
dc.contributor.authorMcMahon, Francis J.
dc.contributor.authorMorris, Derek W.
dc.contributor.authorWilliams, Robert W.
dc.contributor.authorBrunner, Han G.
dc.contributor.authorBuckner, Randy L.
dc.contributor.authorBuitelaar, Jan K.
dc.contributor.authorCahn, Wiepke
dc.contributor.authorCalhoun, Vince D.
dc.contributor.authorCavalleri, Gianpiero L.
dc.contributor.authorCrespo-Facorro, Benedicto
dc.contributor.authorDale, Anders M.
dc.contributor.authorDavies, Gareth E.
dc.contributor.authorDelanty, Norman
dc.contributor.authorDepondt, Chantal
dc.contributor.authorDjurovic, Srdjan
dc.contributor.authorDrevets, Wayne C.
dc.contributor.authorEspeseth, Thomas
dc.contributor.authorGollub, Randy L.
dc.contributor.authorHo, Beng-Choon
dc.contributor.authorHoffmann, Wolfgang
dc.contributor.authorHosten, Norbert
dc.contributor.authorKahn, René S.
dc.contributor.authorLe Hellard, Stephanie
dc.contributor.authorMeyer-Lindenberg, Andreas
dc.contributor.authorMüller-Myhsok, Bertram
dc.contributor.authorNauck, Matthias
dc.contributor.authorNyberg, Lars
dc.contributor.authorPandolfo, Massimo
dc.contributor.authorPenninx, Brenda W. J. H.
dc.contributor.authorRoffman, Joshua L.
dc.contributor.authorSisodiya, Sanjay M.
dc.contributor.authorSmoller, Jordan W.
dc.contributor.authorvan Bokhoven, Hans
dc.contributor.authorvan Haren, Neeltje E. M.
dc.contributor.authorVölzke, Henry
dc.contributor.authorWalter, Henrik
dc.contributor.authorWeiner, Michael W.
dc.contributor.authorWen, Wei
dc.contributor.authorWhite, Tonya
dc.contributor.authorAgartz, Ingrid
dc.contributor.authorAndreassen, Ole A.
dc.contributor.authorBlangero, John
dc.contributor.authorBoomsma, Dorret I.
dc.contributor.authorBrouwer, Rachel M.
dc.contributor.authorCannon, Dara M.
dc.contributor.authorCookson, Mark R.
dc.contributor.authorde Geus, Eco J. C.
dc.contributor.authorDeary, Ian J.
dc.contributor.authorDonohoe, Gary
dc.contributor.authorFernández, Guillén
dc.contributor.authorFisher, Simon E.
dc.contributor.authorFrancks, Clyde
dc.contributor.authorGlahn, David C.
dc.contributor.authorGrabe, Hans J.
dc.contributor.authorGruber, Oliver
dc.contributor.authorHardy, John
dc.contributor.authorHashimoto, Ryota
dc.contributor.authorHulshoff Pol, Hilleke E.
dc.contributor.authorJönsson, Erik G.
dc.contributor.authorKloszewska, Iwona
dc.contributor.authorLovestone, Simon
dc.contributor.authorMattay, Venkata S.
dc.contributor.authorMecocci, Patrizia
dc.contributor.authorMcDonald, Colm
dc.contributor.authorMcIntosh, Andrew M.
dc.contributor.authorOphoff, Roel A.
dc.contributor.authorPaus, Tomas
dc.contributor.authorPausova, Zdenka
dc.contributor.authorRyten, Mina
dc.contributor.authorSachdev, Perminder S.
dc.contributor.authorSaykin, Andrew J.
dc.contributor.authorSimmons, Andy
dc.contributor.authorSingleton, Andrew
dc.contributor.authorSoininen, Hilkka
dc.contributor.authorWardlaw, Joanna M.
dc.contributor.authorWeale, Michael E.
dc.contributor.authorWeinberger, Daniel R.
dc.contributor.authorAdams, Hieab H. H.
dc.contributor.authorLauner, Lenore J.
dc.contributor.authorSeiler, Stephan
dc.contributor.authorSchmidt, Reinhold
dc.contributor.authorChauhan, Ganesh
dc.contributor.authorSatizabal, Claudia L.
dc.contributor.authorBecker, James T.
dc.contributor.authorYanek, Lisa
dc.contributor.authorvan der Lee, Sven J.
dc.contributor.authorEbling, Maritza
dc.contributor.authorFischl, Bruce
dc.contributor.authorLongstreth, W. T.
dc.contributor.authorGreve, Douglas
dc.contributor.authorSchmidt, Helena
dc.contributor.authorNyquist, Paul
dc.contributor.authorVinke, Louis N.
dc.contributor.authorvan Duijn, Cornelia M.
dc.contributor.authorXue, Luting
dc.contributor.authorMazoyer, Bernard
dc.contributor.authorBis, Joshua C.
dc.contributor.authorGudnason, Vilmundur
dc.contributor.authorSeshadri, Sudha
dc.contributor.authorIkram, M. Arfan
dc.contributor.authorMartin, Nicholas G.
dc.contributor.authorWright, Margaret J.
dc.contributor.authorSchumann, Gunter
dc.contributor.authorFranke, Barbara
dc.contributor.authorThompson, Paul M.
dc.contributor.authorMedland, Sarah E.
dc.contributor.departmentDepartment of Radiology and Imaging Sciences, IU School of Medicineen_US
dc.date.accessioned2016-03-14T22:15:38Z
dc.date.available2016-03-14T22:15:38Z
dc.date.issued2015-04-09
dc.description.abstractThe highly complex structure of the human brain is strongly shaped by genetic influences. Subcortical brain regions form circuits with cortical areas to coordinate movement, learning, memory and motivation, and altered circuits can lead to abnormal behaviour and disease. To investigate how common genetic variants affect the structure of these brain regions, here we conduct genome-wide association studies of the volumes of seven subcortical regions and the intracranial volume derived from magnetic resonance images of 30,717 individuals from 50 cohorts. We identify five novel genetic variants influencing the volumes of the putamen and caudate nucleus. We also find stronger evidence for three loci with previously established influences on hippocampal volume and intracranial volume. These variants show specific volumetric effects on brain structures rather than global effects across structures. The strongest effects were found for the putamen, where a novel intergenic locus with replicable influence on volume (rs945270en_US
dc.description.abstractP = 1.08 × 10−33en_US
dc.description.abstract0.52% variance explained) showed evidence of altering the expression of the KTN1 gene in both brain and blood tissue. Variants influencing putamen volume clustered near developmental genes that regulate apoptosis, axon guidance and vesicle transport. Identification of these genetic variants provides insight into the causes of variability inhuman brain development, and may help to determine mechanisms of neuropsychiatric dysfunction.en_US
dc.eprint.versionAuthor's manuscripten_US
dc.identifier.citationHibar, D. P., Stein, J. L., Renteria, M. E., Arias-Vasquez, A., Desrivières, S., Jahanshad, N., … Medland, S. E. (2015). Common genetic variants influence human subcortical brain structures. Nature, 520(7546), 224–229. http://doi.org/10.1038/nature14101en_US
dc.identifier.issn0028-0836en_US
dc.identifier.urihttps://hdl.handle.net/1805/8847
dc.language.isoen_USen_US
dc.publisherNature Publishing Groupen_US
dc.relation.isversionof10.1038/nature14101en_US
dc.relation.journalNatureen_US
dc.rightsPublisher Policyen_US
dc.sourcePMCen_US
dc.subjectBrainen_US
dc.subjectanatomy & histologyen_US
dc.subjectGenetic Variationen_US
dc.subjectgeneticsen_US
dc.subjectGenome-Wide Association Studyen_US
dc.titleCommon genetic variants influence human subcortical brain structuresen_US
dc.typeArticleen_US
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