Type 2 diabetes mellitus is associated with brain atrophy and hypometabolism in the ADNI cohort
dc.contributor.author | Li, Wei | |
dc.contributor.author | Risacher, Shannon L. | |
dc.contributor.author | Huang, Edgar | |
dc.contributor.author | Saykin, Andrew J. | |
dc.contributor.department | Radiology and Imaging Sciences, School of Medicine | en_US |
dc.date.accessioned | 2018-02-27T21:30:39Z | |
dc.date.available | 2018-02-27T21:30:39Z | |
dc.date.issued | 2016-08-09 | |
dc.description.abstract | Objective: We investigated type 2 diabetes mellitus (T2DM) as a risk factor for brain atrophy and glucose hypometabolism in older adults with or at risk of cognitive impairment. Methods: Participants with the T2DM were identified from the Alzheimer's Disease Neuroimaging Initiative (ADNI-1/GO/2 cohorts). Analysis of covariance models were used to compare participants with and without T2DM, controlling for potential confounding factors. Results: Whole brain volume and whole brain [18F]-fluorodeoxyglucose (FDG) uptake were significantly different as a function of T2DM status, independent of baseline clinical diagnosis. On post hoc analysis, a lower whole brain volume was seen in participants with both mild cognitive impairment (MCI) and T2DM (n = 76) compared with participants who had MCI but not T2DM (n = 747; p = 0.009). Similarly, mean FDG uptake in gray matter and white matter was lower in participants with both MCI and T2DM (n = 72) than in participants with MCI without T2DM (n = 719; p = 0.04). Subsequent regional analysis revealed that the decreased FDG uptake in participants with both MCI and T2DM was mainly manifested in 3 brain regions: frontal lobe, sensory motor cortex, and striatum. Conclusions: T2DM may accelerate cognition deterioration in patients with MCI by affecting glucose metabolism and brain volume. | en_US |
dc.eprint.version | Final published version | en_US |
dc.identifier.citation | Li, W., Risacher, S. L., Huang, E., & Saykin, A. J. (2016). Type 2 diabetes mellitus is associated with brain atrophy and hypometabolism in the ADNI cohort. Neurology, 87(6), 595–600. https://doi.org/10.1212/WNL.0000000000002950 | en_US |
dc.identifier.issn | 0028-3878 | en_US |
dc.identifier.uri | https://hdl.handle.net/1805/15294 | |
dc.language.iso | en_US | en_US |
dc.publisher | AAN | en_US |
dc.relation.isversionof | 10.1212/WNL.0000000000002950 | en_US |
dc.relation.journal | Neurology | en_US |
dc.rights | Publisher Policy | en_US |
dc.source | PMC | en_US |
dc.subject | diabetes mellitus | en_US |
dc.subject | brain | en_US |
dc.subject | hypometabolism | en_US |
dc.title | Type 2 diabetes mellitus is associated with brain atrophy and hypometabolism in the ADNI cohort | en_US |
dc.type | Article | en_US |
ul.alternative.fulltext | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4977372/ | en_US |