The hedgehog's trick for escaping immunosurveillance: The molecular mechanisms driving myeloid-derived suppressor cell recruitment in hedgehog signaling-dependent tumors

Simple item page
dc.contributor.authorXie, Jingwu
dc.contributor.departmentPediatrics, School of Medicine
dc.date.accessioned2025-04-01T13:34:19Z
dc.date.available2025-04-01T13:34:19Z
dc.date.issued2014-06-05
dc.description.abstractMyeloid-derived suppressor cells (MDSCs) are an important means by which tumor cells evade immunosurveillance. Here, we set out to determine how MDSCs are recruited to tumors in genetically engineered mouse cancer models. Expression of oncogenic and constitutively active SmoM2, a key hedgehog-signaling regulatory protein, revealed that MDSC recruitment to the tumor microenvironment is mediated by the CCL2/CCR2 axis in a TGFβ dependent fashion.
dc.eprint.versionFinal published version
dc.identifier.citationXie J. The hedgehog's trick for escaping immunosurveillance: The molecular mechanisms driving myeloid-derived suppressor cell recruitment in hedgehog signaling-dependent tumors. Oncoimmunology. 2014;3:e29180. Published 2014 Jun 5. doi:10.4161/onci.29180
dc.identifier.urihttps://hdl.handle.net/1805/46740
dc.language.isoen_US
dc.publisherTaylor & Francis
dc.relation.isversionof10.4161/onci.29180
dc.relation.journalOncoImmunology
dc.rightsAttribution-NonCommercial 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/
dc.sourcePMC
dc.subjectCCL2
dc.subjectMDSC
dc.subjectBasal cell carcinoma
dc.subjectCancer
dc.subjectHedgehog
dc.subjectImmune suppression
dc.subjectMouse models
dc.subjectRhabdomyosarcoma
dc.subjectSmoothened
dc.subjectTumor microenvironment
dc.titleThe hedgehog's trick for escaping immunosurveillance: The molecular mechanisms driving myeloid-derived suppressor cell recruitment in hedgehog signaling-dependent tumors
dc.typeArticle
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Xie2014Hedgehog-CCBYNC.pdf
Size:
740.66 KB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
2.04 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Open Access Policy Articles
Department of Pediatrics Works