Biofilm Derived Oxylipin Mediated Autoimmune Response in Breast Implant Subjects

dc.contributor.authorKhan, Imran
dc.contributor.authorMinto, Robert E.
dc.contributor.authorKelley-Patteson, Christine
dc.contributor.authorNatta, Bruce W. Van
dc.contributor.authorNeumann, Colby R.
dc.contributor.authorSuh, Lily J.
dc.contributor.authorSingh, Kanhaiya
dc.contributor.authorLester, Mary
dc.contributor.authorVonDerHaar, R. Jason
dc.contributor.authorGordillo, Gayle M.
dc.contributor.authorHassanein, Aladdin H.
dc.contributor.authorSen, Chandan K.
dc.contributor.authorKadin, Marshall E.
dc.contributor.authorSinha, Mithun
dc.contributor.departmentChemistry and Chemical Biology, School of Scienceen_US
dc.date.accessioned2022-01-12T19:36:02Z
dc.date.available2022-01-12T19:36:02Z
dc.date.issued2020-11-20
dc.description.abstractOver 10 million women worldwide have breast implants for breast cancer/prophylactic reconstruction or cosmetic augmentation. In recent years, a number of patients have described a constellation of symptoms that are believed to be related to their breast implants. This constellation of symptoms has been named Breast Implant Illness (BII). The symptoms described include chronic fatigue, joint pain, muscle pain and a host of other manifestations often associated with autoimmune illnesses. In this work, we report that bacterial biofilm is associated with BII. We postulate that the pathogenesis of BII is mediated via a host-pathogen interaction whereby the biofilm bacteria Staphylococcus epidermidis interacts with breast lipids to form the oxylipin 10-HOME. The oxylipin 10-HOME was found to activate CD4+ T cells to Th1 subtype. An increased abundance of CD4+Th1 was observed in the breast tissue of BII subjects. The identification of a mechanism of immune activation associated with BII via a biofilm enabled pathway provides insight into the pathogenesis for implant-associated autoimmune symptoms.en_US
dc.eprint.versionAuthor's manuscripten_US
dc.identifier.citationKhan, I., Minto, R. E., Kelley-Patteson, C., Natta, B. W. V., Neumann, C. R., Suh, L. J., Singh, K., Lester, M., VonDerHaar, R. J., Gordillo, G. M., Hassanein, A. H., Sen, C. K., Kadin, M. E., & Sinha, M. (2020). Biofilm Derived Oxylipin Mediated Autoimmune Response in Breast Implant Subjects. MedRxiv, 2020.11.18.20233510. https://doi.org/10.1101/2020.11.18.20233510en_US
dc.identifier.urihttps://hdl.handle.net/1805/27402
dc.language.isoenen_US
dc.publishermedRxiven_US
dc.relation.isversionof10.1101/2020.11.18.20233510en_US
dc.relation.journalmedRxiven_US
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0*
dc.sourceOtheren_US
dc.subjectBreast Implantsen_US
dc.subjectPlastic Surgeryen_US
dc.subjectAutoimmune responseen_US
dc.titleBiofilm Derived Oxylipin Mediated Autoimmune Response in Breast Implant Subjectsen_US
dc.typeArticleen_US
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