Role of inflammatory cells in pathophysiology and management of diabetic retinopathy

dc.contributor.authorKovoor, Elias
dc.contributor.authorChauhan, Sunil K.
dc.contributor.authorHajrasouliha, Amir
dc.contributor.departmentOphthalmology, School of Medicine
dc.date.accessioned2024-01-23T20:16:40Z
dc.date.available2024-01-23T20:16:40Z
dc.date.issued2022-11
dc.description.abstractDiabetic retinopathy (DR) is a sight-threatening complication of diabetes mellitus. Several inflammatory cells and proteins, including macrophages and microglia, cytokines, and vascular endothelial growth factors, are found to play a significant role in the development and progression of DR. Inflammatory cells play a significant role in the earliest changes seen in DR including the breakdown of the blood retinal barrier leading to leakage of blood into the retina. They also have an important role in the pathogenesis of more advanced stage of proliferative diabetic retinopathy, leading to neovascularization, vitreous hemorrhage, and tractional retinal detachment. In this review, we examine the function of numerous inflammatory cells involved in the pathogenesis, progression, and role as a potential therapeutic target in DR. Additionally, we explore the role of inflammation following treatment of DR.
dc.eprint.versionAuthor's manuscript
dc.identifier.citationKovoor, E., Chauhan, S. K., & Hajrasouliha, A. (2022). Role of inflammatory cells in pathophysiology and management of diabetic retinopathy. Survey of Ophthalmology, 67(6), 1563–1573. https://doi.org/10.1016/j.survophthal.2022.07.008
dc.identifier.urihttps://hdl.handle.net/1805/38133
dc.language.isoen_US
dc.publisherElsevier
dc.relation.isversionof10.1016/j.survophthal.2022.07.008
dc.relation.journalSurvey of Ophthalmology
dc.rightsPublisher Policy
dc.sourceAuthor
dc.subjectdiabetic retinopathy
dc.subjectinflammation
dc.subjectimmune cells
dc.subjectvascular proliferation
dc.subjectintravitreal injection
dc.titleRole of inflammatory cells in pathophysiology and management of diabetic retinopathy
dc.typeArticle
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