Enhanced cancer therapy with cold-controlled drug release and photothermal warming enabled by one nanoplatform
dc.contributor.author | Wang, Hai | |
dc.contributor.author | Agarwal, Pranay | |
dc.contributor.author | Liang, Yutong | |
dc.contributor.author | Xu, Jiangsheng | |
dc.contributor.author | Zhao, Gang | |
dc.contributor.author | Tkaczuk, Katherine H. R. | |
dc.contributor.author | Lu, Xiongbin | |
dc.contributor.author | He, Xiaoming | |
dc.contributor.department | Medical and Molecular Genetics, School of Medicine | en_US |
dc.date.accessioned | 2018-08-31T18:50:09Z | |
dc.date.available | 2018-08-31T18:50:09Z | |
dc.date.issued | 2018-10 | |
dc.description.abstract | Stimuli-responsive nanoparticles hold great promise for drug delivery to improve the safety and efficacy of cancer therapy. One of the most investigated stimuli-responsive strategies is to induce drug release by heating with laser, ultrasound, or electromagnetic field. More recently, cryosurgery (also called cryotherapy and cryoablation), destruction of diseased tissues by first cooling/freezing and then warming back, has been used to treat various diseases including cancer in the clinic. Here we developed a cold-responsive nanoparticle for controlled drug release as a result of the irreversible disassembly of the nanoparticle when cooled to below ∼10 °C. Furthermore, this nanoparticle can be used to generate localized heating under near infrared (NIR) laser irradiation, which can facilitate the warming process after cooling/freezing during cryosurgery. Indeed, the combination of this cold-responsive nanoparticle with ice cooling and NIR laser irradiation can greatly augment cancer destruction both in vitro and in vivo with no evident systemic toxicity. | en_US |
dc.eprint.version | Author's manuscript | en_US |
dc.identifier.citation | Wang, H., Agarwal, P., Liang, Y., Xu, J., Zhao, G., Tkaczuk, K. H. R., … He, X. (2018). Enhanced cancer therapy with cold-controlled drug release and photothermal warming enabled with one nanoplatform. Biomaterials. https://doi.org/10.1016/j.biomaterials.2018.07.021 | en_US |
dc.identifier.uri | https://hdl.handle.net/1805/17275 | |
dc.language.iso | en | en_US |
dc.publisher | Elsevier | en_US |
dc.relation.isversionof | 10.1016/j.biomaterials.2018.07.021 | en_US |
dc.relation.journal | Biomaterials | en_US |
dc.rights | Publisher Policy | en_US |
dc.source | Author | en_US |
dc.subject | cold-responsive | en_US |
dc.subject | NIPAM | en_US |
dc.subject | PLGA | en_US |
dc.title | Enhanced cancer therapy with cold-controlled drug release and photothermal warming enabled by one nanoplatform | en_US |
dc.type | Article | en_US |