Synthesis and Structural Characterization of 2′-Deoxy-2′-fluoro-l-uridine Nucleic Acids
dc.contributor.author | Dantsu, Yuliya | |
dc.contributor.author | Zhang, Ying | |
dc.contributor.author | Zhang, Wen | |
dc.contributor.department | Biochemistry and Molecular Biology, School of Medicine | en_US |
dc.date.accessioned | 2023-04-07T20:14:17Z | |
dc.date.available | 2023-04-07T20:14:17Z | |
dc.date.issued | 2021-06 | |
dc.description.abstract | Despite the development of artificial l-RNA/DNA as therapeutic molecules, the in-depth investigation on their chemical modifications is still limited. Here, we synthesize a chemically derivatized 2′-deoxy-2′-fluoro-l-uridine building block and incorporate it into oligonucleotides. Our thermo-denaturization and enzymatic digestion experiments reveal their superior stability. Furthermore, one crystal structure of l-type fluoro-DNA is determined to characterize its handedness. Our results reveal the increase of l-helix stability by fluoro-modification and provide the foundation for its future functional application. | en_US |
dc.eprint.version | Author's manuscript | en_US |
dc.identifier.citation | Dantsu, Y., Zhang, Y., & Zhang, W. (2021). Synthesis and Structural Characterization of 2′-Deoxy-2′-fluoro-l-uridine Nucleic Acids. Organic Letters, 23(13), 5007–5011. https://doi.org/10.1021/acs.orglett.1c01498 | en_US |
dc.identifier.issn | 1523-7060, 1523-7052 | en_US |
dc.identifier.uri | https://hdl.handle.net/1805/32294 | |
dc.language.iso | en_US | en_US |
dc.publisher | ACS | en_US |
dc.relation.isversionof | 10.1021/acs.orglett.1c01498 | en_US |
dc.relation.journal | Organic Letters | en_US |
dc.rights | Publisher Policy | en_US |
dc.source | Author | en_US |
dc.subject | Nucleic acids | en_US |
dc.subject | Biopolymers | en_US |
dc.subject | Crystal structure | en_US |
dc.subject | Genetics | en_US |
dc.title | Synthesis and Structural Characterization of 2′-Deoxy-2′-fluoro-l-uridine Nucleic Acids | en_US |
dc.type | Article | en_US |