Oral Glucose Tolerance Test Measures of First-phase Insulin Response and Their Predictive Ability for Type 1 Diabetes
dc.contributor.author | Baidal, David A. | |
dc.contributor.author | Warnock, Megan | |
dc.contributor.author | Xu, Ping | |
dc.contributor.author | Geyer, Susan | |
dc.contributor.author | Marks, Jennifer B. | |
dc.contributor.author | Moran, Antoinette | |
dc.contributor.author | Sosenko, Jay | |
dc.contributor.author | Evans-Molina, Carmella | |
dc.contributor.department | Pediatrics, School of Medicine | |
dc.date.accessioned | 2024-01-03T09:53:57Z | |
dc.date.available | 2024-01-03T09:53:57Z | |
dc.date.issued | 2022 | |
dc.description.abstract | Context: Decreased first-phase insulin response (FPIR) during intravenous glucose tolerance testing (IVGTT) is an early indicator of β-cell dysfunction and predictor of type 1 diabetes (T1D). Objective: Assess whether oral glucose tolerance test (OGTT) measures could serve as FPIR alternatives in their ability to predict T1D in autoantibody positive (Aab+) subjects. Design: OGTT and IVGTT were performed within 30 days of each other. Eleven OGTT variables were evaluated for (1) correlation with FPIR and (2) T1D prediction. Setting: Type 1 Diabetes TrialNet "Oral Insulin for Prevention of Diabetes in Relatives at Risk for T1D" (TN-07) and Diabetes Prevention Trial-Type 1 Diabetes (DPT-1) studies clinical sites. Patients: TN-07 (n = 292; age 9.4 ± 6.1 years) and DPT-1 (n = 194; age 15.1 ± 10.0 years) Aab + relatives of T1D individuals. Main outcome measures: (1) Correlation coefficients of OGTT measures with FPIR and (2) T1D prediction at 2 years using area under receiver operating characteristic (ROCAUC) curves. Results: Index60 showed the strongest correlation in DPT-1 (r = -0.562) but was weaker in TN-07 (r = -0.378). C-peptide index consistently showed good correlation with FPIR across studies (TN-07, r = 0.583; DPT-1, r = 0.544; P < 0.0001). Index60 and C-peptide index had the highest ROCAUCs for T1D prediction (0.778 vs 0.717 in TN-07 and 0.763 vs 0.721 in DPT-1, respectively; P = NS), followed by FPIR (0.707 in TN-07; 0.628 in DPT-1). Conclusions: C-peptide index was the strongest measure to correlate with FPIR in both studies. Index60 and C-peptide index had the highest predictive accuracy for T1D and were comparable. OGTTs could be considered instead of IVGTTs for subject stratification in T1D prevention trials. | |
dc.identifier.citation | Baidal DA, Warnock M, Xu P, et al. Oral Glucose Tolerance Test Measures of First-phase Insulin Response and Their Predictive Ability for Type 1 Diabetes. J Clin Endocrinol Metab. 2022;107(8):e3273-e3280. doi:10.1210/clinem/dgac285 | |
dc.identifier.uri | https://hdl.handle.net/1805/37563 | |
dc.language.iso | en_US | |
dc.publisher | Oxford University Press | |
dc.relation.isversionof | 10.1210/clinem/dgac285 | |
dc.relation.journal | The Journal of Clinical Endocrinology & Metabolism | |
dc.rights | Publisher Policy | |
dc.source | PMC | |
dc.subject | Type 1 diabetes | |
dc.subject | First-phase insulin response | |
dc.subject | C-peptide index | |
dc.subject | Index60 | |
dc.subject | Oral glucose tolerance test | |
dc.subject | TrialNet | |
dc.title | Oral Glucose Tolerance Test Measures of First-phase Insulin Response and Their Predictive Ability for Type 1 Diabetes | |
dc.type | Article | |
ul.alternative.fulltext | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9282258/ |
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