History of Glial Cell Line-Derived Neurotrophic Factor (GDNF) and Its Use for Spinal Cord Injury Repair

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dc.contributor.authorWalker, Melissa J.
dc.contributor.authorXu, Xiao-Ming
dc.contributor.departmentNeurological Surgery, School of Medicineen_US
dc.date.accessioned2018-07-25T16:07:43Z
dc.date.available2018-07-25T16:07:43Z
dc.date.issued2018-06-13
dc.description.abstractFollowing an initial mechanical insult, traumatic spinal cord injury (SCI) induces a secondary wave of injury, resulting in a toxic lesion environment inhibitory to axonal regeneration. This review focuses on the glial cell line-derived neurotrophic factor (GDNF) and its application, in combination with other factors and cell transplantations, for repairing the injured spinal cord. As studies of recent decades strongly suggest that combinational treatment approaches hold the greatest therapeutic potential for the central nervous system (CNS) trauma, future directions of combinational therapies will also be discussed.en_US
dc.eprint.versionFinal published versionen_US
dc.identifier.citationWalker, M. J., & Xu, X.-M. (2018). History of Glial Cell Line-Derived Neurotrophic Factor (GDNF) and Its Use for Spinal Cord Injury Repair. Brain Sciences, 8(6), 109. https://doi.org/10.3390/brainsci8060109en_US
dc.identifier.urihttps://hdl.handle.net/1805/16798
dc.language.isoen_USen_US
dc.publisherMDPIen_US
dc.relation.isversionof10.3390/brainsci8060109en_US
dc.relation.journalBrain Sciencesen_US
dc.rightsAttribution 3.0 United States
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/
dc.sourcePublisheren_US
dc.subjectspinal cord injuryen_US
dc.subjectglial cell line-derived neurotrophic factoren_US
dc.subjectGFRα-1en_US
dc.subjectcRETen_US
dc.subjectSchwann cellsen_US
dc.subjectastrogliosisen_US
dc.subjectneuroprotectionen_US
dc.subjectaxonal regenerationen_US
dc.subjectcombinational therapiesen_US
dc.subjectneurotraumaen_US
dc.titleHistory of Glial Cell Line-Derived Neurotrophic Factor (GDNF) and Its Use for Spinal Cord Injury Repairen_US
dc.typeArticleen_US
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