Longitudinal cognitive performance of participants with sporadic early onset Alzheimer's disease from LEADS

dc.contributor.authorHammers, Dustin B.
dc.contributor.authorEloyan, Ani
dc.contributor.authorTaurone, Alexander
dc.contributor.authorThangarajah, Maryanne
dc.contributor.authorGao, Sujuan
dc.contributor.authorBeckett, Laurel
dc.contributor.authorPolsinelli, Angelina J.
dc.contributor.authorKirby, Kala
dc.contributor.authorDage, Jeffrey L.
dc.contributor.authorNudelman, Kelly
dc.contributor.authorAisen, Paul
dc.contributor.authorReman, Rema
dc.contributor.authorLa Joie, Renaud
dc.contributor.authorLagarde, Julien
dc.contributor.authorAtri, Alireza
dc.contributor.authorClark, David
dc.contributor.authorDay, Gregory S.
dc.contributor.authorDuara, Ranjan
dc.contributor.authorGraff-Radford, Neill R.
dc.contributor.authorGrant, Ian
dc.contributor.authorHonig, Lawrence S.
dc.contributor.authorJohnson, Erik C. B.
dc.contributor.authorJones, David T.
dc.contributor.authorMasdeu, Joseph C.
dc.contributor.authorMendez, Mario F.
dc.contributor.authorWomack, Kyle
dc.contributor.authorMusiek, Erik
dc.contributor.authorOnyike, Chiadi U.
dc.contributor.authorRiddle, Meghan
dc.contributor.authorRogalski, Emily
dc.contributor.authorSalloway, Steven
dc.contributor.authorSha, Sharon J.
dc.contributor.authorTurner, Raymond Scott
dc.contributor.authorWingo, Thomas S.
dc.contributor.authorWolk, David A.
dc.contributor.authorCarrillo, Maria C.
dc.contributor.authorRabinovici, Gil D.
dc.contributor.authorDickerson, Bradford C.
dc.contributor.authorApostolova, Liana G.
dc.contributor.authorLEADS Consortium
dc.contributor.departmentNeurology, School of Medicine
dc.date.accessioned2025-03-20T12:36:25Z
dc.date.available2025-03-20T12:36:25Z
dc.date.issued2025
dc.description.abstractIntroduction: Early-onset Alzheimer's disease (EOAD) manifests prior to the age of 65, and affects 4%-8% of patients with Alzheimer's disease (AD). The current analyses sought to examine longitudinal cognitive trajectories of participants with early-onset dementia. Methods: Data from 307 cognitively normal (CN) volunteer participants and those with amyloid-positive EOAD or amyloid-negative cognitive impairment (EOnonAD) were compared. Cognitive trajectories across a comprehensive cognitive battery spanning 42 months were examined using mixed-effects modeling. Results: The EOAD group displayed worse cognition at baseline relative to EOnonAD and CN groups, and more aggressive declines in cognition over time. The largest effects were observed on measures of executive functioning domains, while memory declines were blunted in EOAD. Discussion: EOAD declined 2-4× faster than EOnonAD, and EOAD pathology is not restricted to memory networks. Early identification of deficits is critical to ensure that individuals with sporadic EOAD can be considered for treatment using disease-modifying medications. Highlights: Represents the most comprehensive longitudinal characterization of sporadic EOAD to date. The trajectory of cognitive declines was steep for EOAD participants and worse than for other groups. Executive functioning measures exhibited the greatest declines over time in EOAD.
dc.eprint.versionFinal published version
dc.identifier.citationHammers DB, Eloyan A, Taurone A, et al. Longitudinal cognitive performance of participants with sporadic early onset Alzheimer's disease from LEADS. Alzheimers Dement. 2025;21(2):e14439. doi:10.1002/alz.14439
dc.identifier.urihttps://hdl.handle.net/1805/46408
dc.language.isoen_US
dc.publisherWiley
dc.relation.isversionof10.1002/alz.14439
dc.relation.journalAlzheimer's & Dementia
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.sourcePMC
dc.subjectAlzheimer's disease
dc.subjectAmnestic
dc.subjectAtypical variant
dc.subjectEarly‐onset
dc.subjectLongitudinal
dc.titleLongitudinal cognitive performance of participants with sporadic early onset Alzheimer's disease from LEADS
dc.typeArticle
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