Dispensability of Ascorbic Acid Uptake and Utilization Encoded by ulaABCD for the Virulence of Haemophilus ducreyi in Humans

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dc.contributor.authorBrothwell, Julie A.
dc.contributor.authorFortney, Kate R.
dc.contributor.authorBatteiger, Teresa
dc.contributor.authorKatz, Barry P.
dc.contributor.authorSpinola, Stanley M.
dc.contributor.departmentMicrobiology and Immunology, School of Medicine
dc.date.accessioned2024-02-09T13:31:44Z
dc.date.available2024-02-09T13:31:44Z
dc.date.issued2023
dc.description.abstractCompared with wounded skin, ascorbic acid is enriched in pustules of humans experimentally infected with Haemophilus ducreyi. Compared with the broth-grown inocula, transcription of the H. ducreyi ulaABCD operon, which encodes genes for ascorbic acid uptake, is increased in pustules. We hypothesized that ascorbic acid uptake plays a role in H. ducreyi virulence. Five volunteers were infected with both H. ducreyi strain 35000HP and its isogenic ulaABCD deletion mutant at multiple sites; the papule and pustule formation rates of the mutant and parent strains were similar. Thus, ascorbic acid uptake is not essential for H. ducreyi virulence in humans.
dc.eprint.versionFinal published version
dc.identifier.citationBrothwell JA, Fortney KR, Batteiger T, Katz BP, Spinola SM. Dispensability of Ascorbic Acid Uptake and Utilization Encoded by ulaABCD for the Virulence of Haemophilus ducreyi in Humans. J Infect Dis. 2023;227(3):317-321. doi:10.1093/infdis/jiac314
dc.identifier.urihttps://hdl.handle.net/1805/38363
dc.language.isoen_US
dc.publisherOxford University Press
dc.relation.isversionof10.1093/infdis/jiac314
dc.relation.journalThe Journal of Infectious Diseases
dc.rightsPublisher Policy
dc.sourcePMC
dc.subjectHaemophilus ducreyi
dc.subjectAbscess
dc.subjectAscorbic acid
dc.subjectHuman challenge model
dc.subjectSkin infection
dc.titleDispensability of Ascorbic Acid Uptake and Utilization Encoded by ulaABCD for the Virulence of Haemophilus ducreyi in Humans
dc.typeArticle
ul.alternative.fulltexthttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10169391/
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