A meta-analysis of two genome-wide association studies to identify novel loci for maximum number of alcoholic drinks
dc.contributor.author | Kapoor, Manav | |
dc.contributor.author | Wang, Jen-Chyong | |
dc.contributor.author | Wetherill, Leah | |
dc.contributor.author | Le, Nhung | |
dc.contributor.author | Bertelsen, Sarah | |
dc.contributor.author | Hinrichs, Anthony L. | |
dc.contributor.author | Budde, John | |
dc.contributor.author | Agrawal, Arpana | |
dc.contributor.author | Bucholz, Kathleen | |
dc.contributor.author | Dick, Danielle | |
dc.contributor.author | Harari, Oscar | |
dc.contributor.author | Hesselbrock, Victor | |
dc.contributor.author | Kramer, John | |
dc.contributor.author | Nurnberger, John I., Jr. | |
dc.contributor.author | Rice, John | |
dc.contributor.author | Saccone, Nancy | |
dc.contributor.author | Schuckit, Marc | |
dc.contributor.author | Tischfield, Jay | |
dc.contributor.author | Porjesz, Bernice | |
dc.contributor.author | Edenberg, Howard J. | |
dc.contributor.author | Bierut, Laura | |
dc.contributor.author | Foroud, Tatiana | |
dc.contributor.author | Goate, Alison | |
dc.contributor.department | Medical and Molecular Genetics, School of Medicine | |
dc.date.accessioned | 2025-05-07T13:26:34Z | |
dc.date.available | 2025-05-07T13:26:34Z | |
dc.date.issued | 2013 | |
dc.description.abstract | Maximum number of alcoholic drinks consumed in a 24-h period (maxdrinks) is a heritable (>50 %) trait and is strongly correlated with vulnerability to excessive alcohol consumption and subsequent alcohol dependence (AD). Several genome-wide association studies (GWAS) have studied alcohol dependence, but few have concentrated on excessive alcohol consumption. We performed two GWAS using maxdrinks as an excessive alcohol consumption phenotype: one in 118 extended families (N = 2,322) selected from the Collaborative Study on the Genetics of Alcoholism (COGA), and the other in a case-control sample (N = 2,593) derived from the Study of Addiction: Genes and Environment (SAGE). The strongest association in the COGA families was detected with rs9523562 (p = 2.1 × 10(-6)) located in an intergenic region on chromosome 13q31.1; the strongest association in the SAGE dataset was with rs67666182 (p = 7.1 × 10(-7)), located in an intergenic region on chromosome 8. We also performed a meta-analysis with these two GWAS and demonstrated evidence of association in both datasets for the LMO1 (p = 7.2 × 10(-7)) and PLCL1 genes (p = 4.1 × 10(-6)) with maxdrinks. A variant in AUTS2 and variants in INADL, C15orf32 and HIP1 that were associated with measures of alcohol consumption in a meta-analysis of GWAS studies and a GWAS of alcohol consumption factor score also showed nominal association in the current meta-analysis. The present study has identified several loci that warrant further examination in independent samples. Among the top SNPs in each of the dataset (p ≤ 10(-4)) far more showed the same direction of effect in the other dataset than would be expected by chance (p = 2 × 10(-3), 3 × 10(-6)), suggesting that there are true signals among these top SNPs, even though no SNP reached genome-wide levels of significance. | |
dc.eprint.version | Author's manuscript | |
dc.identifier.citation | Kapoor M, Wang JC, Wetherill L, et al. A meta-analysis of two genome-wide association studies to identify novel loci for maximum number of alcoholic drinks. Hum Genet. 2013;132(10):1141-1151. doi:10.1007/s00439-013-1318-z | |
dc.identifier.uri | https://hdl.handle.net/1805/47857 | |
dc.language.iso | en_US | |
dc.publisher | Springer | |
dc.relation.isversionof | 10.1007/s00439-013-1318-z | |
dc.relation.journal | Human Genetics | |
dc.rights | Publisher Policy | |
dc.source | PMC | |
dc.subject | Alcohol drinking | |
dc.subject | Alcoholism | |
dc.subject | Genetic loci | |
dc.subject | Genome-wide association study | |
dc.title | A meta-analysis of two genome-wide association studies to identify novel loci for maximum number of alcoholic drinks | |
dc.type | Article |