Hippocampal transcriptome-guided genetic analysis of correlated episodic memory phenotypes in Alzheimer's disease

dc.contributor.authorYan, Jingwen
dc.contributor.authorKim, Sungeun
dc.contributor.authorNho, Kwangsik
dc.contributor.authorChen, Rui
dc.contributor.authorRisacher, Shannon L.
dc.contributor.authorMoore, Jason H.
dc.contributor.authorSaykin, Andrew J.
dc.contributor.authorShen, Li
dc.contributor.departmentDepartment of BioHealth Informatics, School of Informatics and Computingen_US
dc.date.accessioned2015-07-15T19:10:57Z
dc.date.available2015-07-15T19:10:57Z
dc.date.issued2015
dc.description.abstractAs the most common type of dementia, Alzheimer's disease (AD) is a neurodegenerative disorder initially manifested by impaired memory performances. While the diagnosis information indicates a dichotomous status of a patient, memory scores have the potential to capture the continuous nature of the disease progression and may provide more insights into the underlying mechanism. In this work, we performed a targeted genetic study of memory scores on an AD cohort to identify the associations between a set of genes highly expressed in the hippocampal region and seven cognitive scores related to episodic memory. Both main effects and interaction effects of the targeted genetic markers on these correlated memory scores were examined. In addition to well-known AD genetic markers APOE and TOMM40, our analysis identified a new risk gene NAV2 through the gene-level main effect analysis. NAV2 was found to be significantly and consistently associated with all seven episodic memory scores. Genetic interaction analysis also yielded a few promising hits warranting further investigation, especially for the RAVLT list B Score.en_US
dc.eprint.versionFinal published versionen_US
dc.identifier.citationYan, J., Kim, S., Nho, K., Chen, R., Risacher, S. L., Moore, J. H., ... & Alzheimer's Disease Neuroimaging Initiative. (2015). Hippocampal transcriptome-guided genetic analysis of correlated episodic memory phenotypes in Alzheimer's disease. Frontiers in genetics, 6.en_US
dc.identifier.urihttps://hdl.handle.net/1805/6565
dc.language.isoen_USen_US
dc.relation.isversionof10.3389/fgene.2015.00117en_US
dc.relation.journalFrontiers in Geneticsen_US
dc.rightsAttribution 3.0 United States
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/
dc.sourcePMCen_US
dc.subjectcorrelated phenotypesen_US
dc.subjectepisodic memoryen_US
dc.subjectAlzheimer's diseaseen_US
dc.titleHippocampal transcriptome-guided genetic analysis of correlated episodic memory phenotypes in Alzheimer's diseaseen_US
dc.typeArticleen_US
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