Weight loss and β-cell responses following gastric banding or pharmacotherapy in adults with impaired glucose tolerance or type 2 diabetes: a randomized trial
dc.contributor.author | Utzschneider, Kristina M. | |
dc.contributor.author | Ehrmann, David A. | |
dc.contributor.author | Arslanian, Silva A. | |
dc.contributor.author | Barengolts, Elena | |
dc.contributor.author | Buchanan, Thomas A. | |
dc.contributor.author | Caprio, Sonia | |
dc.contributor.author | Edelstein, Sharon L. | |
dc.contributor.author | Hannon, Tamara S. | |
dc.contributor.author | Kahn, Steven E. | |
dc.contributor.author | Kozedub, Alexandra | |
dc.contributor.author | Mather, Kieren J. | |
dc.contributor.author | Nadeau, Kristen J. | |
dc.contributor.author | Sam, Susan | |
dc.contributor.author | Tripputi, Mark | |
dc.contributor.author | Xiang, Anny H. | |
dc.contributor.author | El ghormli, Laure | |
dc.contributor.author | The RISE Consortium | |
dc.contributor.department | Medicine, School of Medicine | |
dc.date.accessioned | 2024-06-10T08:45:28Z | |
dc.date.available | 2024-06-10T08:45:28Z | |
dc.date.issued | 2022 | |
dc.description.abstract | Objective: The extent to which weight loss contributes to increases in insulin sensitivity (IS) and β-cell function after surgical or medical intervention has not been directly compared in individuals with impaired glucose tolerance or newly diagnosed type 2 diabetes. Methods: The Restoring Insulin Secretion (RISE) Study included adults in the Beta-Cell Restoration Through Fat Mitigation Study (n = 88 randomized to laparoscopic gastric banding or metformin [MET]) and the Adult Medication Study (n = 267 randomized to placebo, MET, insulin glargine/MET, or liraglutide + MET [L + M]). IS and β-cell responses were measured at baseline and after 12 months by modeling of oral glucose tolerance tests and during arginine-stimulated hyperglycemic clamps. Linear regression models assessed differences between and within treatments over time. Results: BMI decreased in all treatment groups, except placebo, at 12 months. IS increased in all arms except placebo and was inversely correlated with changes in BMI. L + M was the only treatment arm that enhanced multiple measures of β-cell function independent of weight loss. Insulin secretion decreased in the laparoscopic gastric banding arm proportional to increases in IS, with no net benefit on β-cell function. Conclusions: Reducing demand on the β-cell by improving IS through weight loss does not reverse β-cell dysfunction. L + M was the only treatment that enhanced β-cell function. | |
dc.eprint.version | Author's manuscript | |
dc.identifier.citation | Utzschneider KM, Ehrmann DA, Arslanian SA, et al. Weight loss and β-cell responses following gastric banding or pharmacotherapy in adults with impaired glucose tolerance or type 2 diabetes: a randomized trial. Obesity (Silver Spring). 2022;30(8):1579-1588. doi:10.1002/oby.23475 | |
dc.identifier.uri | https://hdl.handle.net/1805/41306 | |
dc.language.iso | en_US | |
dc.publisher | Wiley | |
dc.relation.isversionof | 10.1002/oby.23475 | |
dc.relation.journal | Obesity | |
dc.rights | Publisher Policy | |
dc.source | PMC | |
dc.subject | insulin sensitivity (IS) | |
dc.subject | β-cell function | |
dc.subject | type 2 diabetes | |
dc.title | Weight loss and β-cell responses following gastric banding or pharmacotherapy in adults with impaired glucose tolerance or type 2 diabetes: a randomized trial | |
dc.type | Article |