Clinical characteristics and 12-month outcomes of patients with valvular and non-valvular atrial fibrillation in Kenya

dc.contributor.authorTemu, Tecla M.
dc.contributor.authorLane, Kathleen A.
dc.contributor.authorShen, Changyu
dc.contributor.authorNg'ang'a, Loise
dc.contributor.authorAkwanalo, Constantine O.
dc.contributor.authorChen, Peng-Sheng
dc.contributor.authorEmonyi, Wilfred
dc.contributor.authorHeckbert, Susan R.
dc.contributor.authorKoech, Myra M.
dc.contributor.authorManji, Imran
dc.contributor.authorVatta, Matteo
dc.contributor.authorVelazquez, Eric J.
dc.contributor.authorWessel, Jennifer
dc.contributor.authorKimaiyo, Sylvester
dc.contributor.authorInui, Thomas S.
dc.contributor.authorBloomfield, Gerald S.
dc.contributor.departmentBiostatistics, School of Public Healthen_US
dc.date.accessioned2018-03-19T17:26:37Z
dc.date.available2018-03-19T17:26:37Z
dc.date.issued2017-09-21
dc.description.abstractBackground Atrial fibrillation (AF) is a major contributor to the global cardiovascular disease burden. The clinical profile and outcomes of AF patients with valvular heart diseases in sub-Saharan Africa (SSA) have not been adequately described. We assessed clinical features and 12-month outcomes of patients with valvular AF (vAF) in comparison to AF patients without valvular heart disease (nvAF) in western Kenya. Methods We performed a cohort study with retrospective data gathering to characterize risk factors and prospective data collection to characterize their hospitalization, stroke and mortality rates. Results The AF patients included 77 with vAF and 69 with nvAF. The mean (SD) age of vAF and nvAF patients were 37.9(14.5) and 69.4(12.3) years, respectively. There were significant differences (p<0.001) between vAF and nvAF patients with respect to female sex (78% vs. 55%), rates of hypertension (29% vs. 73%) and heart failure (10% vs. 49%). vAF patients were more likely to be taking anticoagulation therapy compared to those with nvAF (97% vs. 76%; p<0.01). After 12-months of follow-up, the overall mortality, hospitalization and stroke rates for vAF patients were high, at 10%, 34% and 5% respectively, and were similar to the rates in the nvAF patients (15%, 36%, and 5%, respectively). Conclusion Despite younger age and few comorbid conditions, patients with vAF in this developing country setting are at high risk for nonfatal and fatal outcomes, and are in need of interventions to improve short and long-term outcomes.en_US
dc.eprint.versionFinal published versionen_US
dc.identifier.citationTemu, T. M., Lane, K. A., Shen, C., Ng’ang’a, L., Akwanalo, C. O., Chen, P.-S., … Bloomfield, G. S. (2017). Clinical characteristics and 12-month outcomes of patients with valvular and non-valvular atrial fibrillation in Kenya. PLoS ONE, 12(9). https://doi.org/10.1371/journal.pone.0185204en_US
dc.identifier.issn1932-6203en_US
dc.identifier.urihttps://hdl.handle.net/1805/15655
dc.language.isoen_USen_US
dc.publisherPLOSen_US
dc.relation.isversionof10.1371/journal.pone.0185204en_US
dc.relation.journalPLoS ONEen_US
dc.rightsAttribution 3.0 United States
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/
dc.sourcePMCen_US
dc.subjectAtrial fibrillationen_US
dc.subjectcardiovascular diseaseen_US
dc.subjectvalvular heart diseaseen_US
dc.subjectwestern Kenyaen_US
dc.titleClinical characteristics and 12-month outcomes of patients with valvular and non-valvular atrial fibrillation in Kenyaen_US
dc.typeArticleen_US
Files
Original bundle
Now showing 1 - 1 of 1
Loading...
Thumbnail Image
Name:
1.pdf
Size:
1.01 MB
Format:
Adobe Portable Document Format
Description:
Article
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.99 KB
Format:
Item-specific license agreed upon to submission
Description: