A penalized Cox proportional hazards model with multiple time-varying exposures

dc.contributor.authorWang, Chenkun
dc.contributor.authorLiu, Hai
dc.contributor.authorGao, Sujuan
dc.contributor.departmentBiostatistics, School of Public Healthen_US
dc.date.accessioned2017-12-14T16:44:46Z
dc.date.available2017-12-14T16:44:46Z
dc.date.issued2017
dc.description.abstractIn recent pharmacoepidemiology research, the increasing use of electronic medication dispensing data provides an unprecedented opportunity to examine various health outcomes associated with long-term medication usage. Often, patients may take multiple types of medications intended for the same medical condition and the medication exposure status and intensity may vary over time, posing challenges to the statistical modeling of such data. In this article, we propose a penalized Cox proportional hazards (PH) model with multiple functional covariates and potential interaction effects. We also consider constrained coefficient functions to ensure a diminishing medication effect over time. Hypothesis testing of interaction effect and main effect was discussed under the penalized Cox PH model setting. Our simulation studies demonstrate the adequate performance of the proposed methods for both parameter estimation and hypothesis testing. Application to a primary care depression cohort study was also illustrated to examine the effects of two common types of antidepressants on the risk of coronary artery disease.en_US
dc.eprint.versionFinal published versionen_US
dc.identifier.citationWang, C., Liu, H., & Gao, S. (2017). A penalized Cox proportional hazards model with multiple time-varying exposures. The Annals of Applied Statistics, 11(1), 185–201. https://doi.org/10.1214/16-AOAS999en_US
dc.identifier.urihttps://hdl.handle.net/1805/14817
dc.language.isoenen_US
dc.publisherIMSen_US
dc.relation.isversionof10.1214/16-AOAS999en_US
dc.relation.journalThe Annals of Applied Statisticsen_US
dc.rightsPublisher Policyen_US
dc.sourcePublisheren_US
dc.subjectpenalized Cox proportional hazards modelen_US
dc.subjectelectronic medication dispensing dataen_US
dc.titleA penalized Cox proportional hazards model with multiple time-varying exposuresen_US
dc.typeArticleen_US
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