Secondary Structure, a Missing Component of Sequence-Based Minimotif Definitions

dc.contributor.authorSargeant, David P.
dc.contributor.authorGryk, Michael R.
dc.contributor.authorMaciejewski, Mark W.
dc.contributor.authorThapar, Vishal
dc.contributor.authorKundeti, Vamsi
dc.contributor.authorRajasekaran, Sanguthevar
dc.contributor.authorRomero, Pedro
dc.contributor.authorDunker, Keith
dc.contributor.authorLi, Shun-Cheng
dc.contributor.authorKaneko, Tomonori
dc.contributor.authorSchiller, Martin R.
dc.contributor.departmentCenter for Computational Biology and Bioinformatics, School of Medicine
dc.date.accessioned2025-05-30T12:24:59Z
dc.date.available2025-05-30T12:24:59Z
dc.date.issued2012
dc.description.abstractMinimotifs are short contiguous segments of proteins that have a known biological function. The hundreds of thousands of minimotifs discovered thus far are an important part of the theoretical understanding of the specificity of protein-protein interactions, posttranslational modifications, and signal transduction that occur in cells. However, a longstanding problem is that the different abstractions of the sequence definitions do not accurately capture the specificity, despite decades of effort by many labs. We present evidence that structure is an essential component of minimotif specificity, yet is not used in minimotif definitions. Our analysis of several known minimotifs as case studies, analysis of occurrences of minimotifs in structured and disordered regions of proteins, and review of the literature support a new model for minimotif definitions that includes sequence, structure, and function.
dc.eprint.versionFinal published version
dc.identifier.citationSargeant DP, Gryk MR, Maciejewski MW, et al. Secondary structure, a missing component of sequence-based minimotif definitions. PLoS One. 2012;7(12):e49957. doi:10.1371/journal.pone.0049957
dc.identifier.urihttps://hdl.handle.net/1805/48493
dc.language.isoen_US
dc.publisherPublic Library of Science
dc.relation.isversionof10.1371/journal.pone.0049957
dc.relation.journalPLoS One
dc.rightsAttribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourcePMC
dc.subjectAmino acid motifs
dc.subjectSecondary protein structure
dc.subjectProtein sequence analysis
dc.titleSecondary Structure, a Missing Component of Sequence-Based Minimotif Definitions
dc.typeArticle
Files
Original bundle
Now showing 1 - 1 of 1
Loading...
Thumbnail Image
Name:
Sargeant2012Secondary-CCBY.pdf
Size:
852.98 KB
Format:
Adobe Portable Document Format
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
2.04 KB
Format:
Item-specific license agreed upon to submission
Description: