Optic nerve head morphology in glaucoma patients of African descent is strongly correlated to retinal blood flow

dc.contributor.authorKanakamedala, Priyanka
dc.contributor.authorHarris, Alon
dc.contributor.authorSiesky, Brent
dc.contributor.authorTyring, Ariel
dc.contributor.authorMuchnik, Michael
dc.contributor.authorEckert, George
dc.contributor.authorTobe, Leslie Abrams
dc.contributor.departmentOphthalmology, School of Medicineen_US
dc.date.accessioned2015-09-15T17:50:25Z
dc.date.available2015-09-15T17:50:25Z
dc.date.issued2014-11
dc.description.abstractBACKGROUND/AIMS: To examine the relationship between change in optic nerve head (ONH) morphology and retinal blood flow in patients with open-angle glaucoma (OAG) of African (AD) and European descent (ED) over 3 years. METHODS: 112 patients with OAG (29 AD; 83 ED) underwent assessment of ONH morphology using Heidelberg retinal tomography (HRT-III), and retinal blood flow using confocal scanning laser Doppler. Repeated-measures analysis of covariance was used to compare baseline and 3-year measurements, and Pearson correlations were calculated to evaluate the relationships. RESULTS: In OAG patients of AD, change in superior mean retinal blood flow was strongly, negatively correlated with change in cup/disc (C/D) area ratio (r=-0.78, p=0.020) and cup area (r=-0.75, p=0.0283) and strongly, positively correlated with change in rim area (r=0.74, p=0.0328) over 3 years. In OAG patients of AD, change in inferior mean retinal blood flow was strongly, negatively correlated with changes in C/D area ratio (r=-0.88, p=0.0156) and linear C/D ratio (r=-0.86, p=0.0265) over 3 years. In OAG patients of ED, these correlations were weak and did not reach statistical significance. DISCUSSION: OAG patients of AD may have a stronger vascular component to their glaucoma pathophysiology than patients of ED.en_US
dc.eprint.versionAuthor's manuscripten_US
dc.identifier.citationKanakamedala, P., Harris, A., Siesky, B., Tyring, A., Muchnik, M., Eckert, G., & Tobe, L. A. (2014). Optic Nerve Head Morphology in Glaucoma Patients of African Descent is Strongly Correlated to Retinal Blood Flow. The British Journal of Ophthalmology, 98(11), 1551–1554. http://doi.org/10.1136/bjophthalmol-2013-304393en_US
dc.identifier.urihttps://hdl.handle.net/1805/6924
dc.language.isoen_USen_US
dc.publisherBMJen_US
dc.relation.isversionof10.1136/bjophthalmol-2013-304393en_US
dc.relation.journalThe British Journal of Ophthalmologyen_US
dc.rightsPublisher Policyen_US
dc.sourcePMCen_US
dc.subjectGlaucomaen_US
dc.subjectOptic Nerveen_US
dc.subjectRetinaen_US
dc.titleOptic nerve head morphology in glaucoma patients of African descent is strongly correlated to retinal blood flowen_US
dc.typeArticleen_US
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