Optic nerve head morphology in glaucoma patients of African descent is strongly correlated to retinal blood flow
dc.contributor.author | Kanakamedala, Priyanka | |
dc.contributor.author | Harris, Alon | |
dc.contributor.author | Siesky, Brent | |
dc.contributor.author | Tyring, Ariel | |
dc.contributor.author | Muchnik, Michael | |
dc.contributor.author | Eckert, George | |
dc.contributor.author | Tobe, Leslie Abrams | |
dc.contributor.department | Ophthalmology, School of Medicine | en_US |
dc.date.accessioned | 2015-09-15T17:50:25Z | |
dc.date.available | 2015-09-15T17:50:25Z | |
dc.date.issued | 2014-11 | |
dc.description.abstract | BACKGROUND/AIMS: To examine the relationship between change in optic nerve head (ONH) morphology and retinal blood flow in patients with open-angle glaucoma (OAG) of African (AD) and European descent (ED) over 3 years. METHODS: 112 patients with OAG (29 AD; 83 ED) underwent assessment of ONH morphology using Heidelberg retinal tomography (HRT-III), and retinal blood flow using confocal scanning laser Doppler. Repeated-measures analysis of covariance was used to compare baseline and 3-year measurements, and Pearson correlations were calculated to evaluate the relationships. RESULTS: In OAG patients of AD, change in superior mean retinal blood flow was strongly, negatively correlated with change in cup/disc (C/D) area ratio (r=-0.78, p=0.020) and cup area (r=-0.75, p=0.0283) and strongly, positively correlated with change in rim area (r=0.74, p=0.0328) over 3 years. In OAG patients of AD, change in inferior mean retinal blood flow was strongly, negatively correlated with changes in C/D area ratio (r=-0.88, p=0.0156) and linear C/D ratio (r=-0.86, p=0.0265) over 3 years. In OAG patients of ED, these correlations were weak and did not reach statistical significance. DISCUSSION: OAG patients of AD may have a stronger vascular component to their glaucoma pathophysiology than patients of ED. | en_US |
dc.eprint.version | Author's manuscript | en_US |
dc.identifier.citation | Kanakamedala, P., Harris, A., Siesky, B., Tyring, A., Muchnik, M., Eckert, G., & Tobe, L. A. (2014). Optic Nerve Head Morphology in Glaucoma Patients of African Descent is Strongly Correlated to Retinal Blood Flow. The British Journal of Ophthalmology, 98(11), 1551–1554. http://doi.org/10.1136/bjophthalmol-2013-304393 | en_US |
dc.identifier.uri | https://hdl.handle.net/1805/6924 | |
dc.language.iso | en_US | en_US |
dc.publisher | BMJ | en_US |
dc.relation.isversionof | 10.1136/bjophthalmol-2013-304393 | en_US |
dc.relation.journal | The British Journal of Ophthalmology | en_US |
dc.rights | Publisher Policy | en_US |
dc.source | PMC | en_US |
dc.subject | Glaucoma | en_US |
dc.subject | Optic Nerve | en_US |
dc.subject | Retina | en_US |
dc.title | Optic nerve head morphology in glaucoma patients of African descent is strongly correlated to retinal blood flow | en_US |
dc.type | Article | en_US |