Signaling to p53: ribosomal proteins find their way
dc.contributor.author | Zhang, Yanping | |
dc.contributor.author | Lu, Hua | |
dc.contributor.department | Department of Biochemistry & Molecular Biology, IU School of Medicine | en_US |
dc.date.accessioned | 2016-03-03T21:46:23Z | |
dc.date.available | 2016-03-03T21:46:23Z | |
dc.date.issued | 2009-11-03 | |
dc.description.abstract | Inherently disparate cell growth and division, which are intimately coupled through a delicate network of intracellular and extracellular signaling, require ribosomal biogenesis. A number of events imparting instability to ribosomal biogenesis can cause nucleolar stress. In response to this stress, several ribosomal proteins bind to MDM2 and block MDM2-mediated p53 ubiquitination and degradation, resulting in p53-dependent cell cycle arrest. By doing so, the ribosomal proteins play a crucial role in connecting deregulated cell growth with inhibition of cell division. The ribosomal protein-MDM2-p53 signaling pathway provides a molecular switch that may constitute a surveillance network monitoring the integrity of ribosomal biogenesis. | en_US |
dc.eprint.version | Author's manuscript | en_US |
dc.identifier.citation | Zhang, Y., & Lu, H. (2009). Signaling to p53: ribosomal proteins find their way. Cancer Cell, 16(5), 369–377. http://doi.org/10.1016/j.ccr.2009.09.024 | en_US |
dc.identifier.uri | https://hdl.handle.net/1805/8685 | |
dc.language.iso | en_US | en_US |
dc.publisher | Elsevier B.V. | en_US |
dc.relation.isversionof | 10.1016/j.ccr.2009.09.024 | en_US |
dc.relation.journal | Cancer Cell | en_US |
dc.rights | Publisher Policy | en_US |
dc.source | PMC | en_US |
dc.subject | Ribosome biogenesis | en_US |
dc.subject | RPL11 | en_US |
dc.subject | RPL5 | en_US |
dc.subject | RPL23 | en_US |
dc.subject | MDM2 | en_US |
dc.subject | p53 | en_US |
dc.subject | zinc finger | en_US |
dc.subject | Cancer | en_US |
dc.subject | nucleolus | en_US |
dc.title | Signaling to p53: ribosomal proteins find their way | en_US |
dc.type | Article | en_US |