Effects of a High-Protein Diet Including Whole Eggs on Muscle Composition and Indices of Cardiometabolic Health and Systemic Inflammation in Older Adults with Overweight or Obesity: A Randomized Controlled Trial
dc.contributor.author | Wright, Christian S. | |
dc.contributor.author | Zhou, Jing | |
dc.contributor.author | Sayer, R. Drew | |
dc.contributor.author | Kim, Jung Eun | |
dc.contributor.author | Campbell, Wayne W. | |
dc.contributor.department | Physical Therapy, School of Health and Human Sciences | en_US |
dc.date.accessioned | 2019-05-10T17:26:02Z | |
dc.date.available | 2019-05-10T17:26:02Z | |
dc.date.issued | 2018-07-23 | |
dc.description.abstract | Age-related increases in intermuscular adipose tissue (IMAT) impair muscle quality, decrease functional capacity, and promote several cardiometabolic and inflammatory disorders. Whether these age-related alterations in muscle composition improve by consuming a high-protein (HP) diet with whole eggs are unclear. This parallel-design, randomized-controlled trial assessed the effects of a 12-week eucaloric HP diet with three whole eggs per day (1.4 g protein kg-1 day-1) versus a normal-protein diet void of eggs (NP, 0.8 g protein kg-1 day-1) on muscle composition (IMAT), cardiometabolic health, and systemic inflammation in older adults with overweight or obesity (12 men and 10 women; age 70 ± 5 years, BMI 31.3 ± 3.2 kg/m², mean ± SD). No changes in muscle composition were observed over time, independent of protein intake. Total body weight was reduced in both groups (-3.3 ± 1.2%) and lean mass was preserved only with the HP diet. LDL concentration and hip circumference decreased only with the NP diet, while MCP-1 and HsCRP concentrations increased over time in both groups. A HP diet with whole eggs promotes lean mass retention with modest weight loss, but does not positively influence muscle composition, cardiometabolic health or systemic inflammation, compared to a NP diet void of eggs. | en_US |
dc.identifier.citation | Wright, C. S., Zhou, J., Sayer, R. D., Kim, J. E., & Campbell, W. W. (2018). Effects of a High-Protein Diet Including Whole Eggs on Muscle Composition and Indices of Cardiometabolic Health and Systemic Inflammation in Older Adults with Overweight or Obesity: A Randomized Controlled Trial. Nutrients, 10(7), 946. doi:10.3390/nu10070946 | en_US |
dc.identifier.uri | https://hdl.handle.net/1805/19232 | |
dc.language.iso | en_US | en_US |
dc.publisher | MDPI | en_US |
dc.relation.isversionof | 10.3390/nu10070946 | en_US |
dc.relation.journal | Nutrients | en_US |
dc.rights | Attribution-NonCommercial-NoDerivs 3.0 United States | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/us/ | * |
dc.source | PMC | en_US |
dc.subject | Dietary protein | en_US |
dc.subject | Eggs | en_US |
dc.subject | Diet composition | en_US |
dc.subject | Skeletal muscle composition | en_US |
dc.subject | Intermuscular adipose tissue | en_US |
dc.subject | Inflammation | en_US |
dc.title | Effects of a High-Protein Diet Including Whole Eggs on Muscle Composition and Indices of Cardiometabolic Health and Systemic Inflammation in Older Adults with Overweight or Obesity: A Randomized Controlled Trial | en_US |
dc.type | Article | en_US |