Intracellular Nef Detected in Peripheral Blood Mononuclear Cells from HIV Patients

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dc.contributor.authorWang, Ting
dc.contributor.authorGreen, Linden A.
dc.contributor.authorGupta, Samir K.
dc.contributor.authorAmet, Tohti
dc.contributor.authorByrd, Daniel J.
dc.contributor.authorYu, Qigui
dc.contributor.authorTwigg, Homer L.
dc.contributor.authorClauss, Matthias
dc.contributor.departmentDepartment of Microbiology & Immunology, IU School of Medicineen_US
dc.date.accessioned2016-03-31T17:33:45Z
dc.date.available2016-03-31T17:33:45Z
dc.date.issued2014-07-25
dc.description.abstractWe report here the novel finding that HIV-negative factor (Nef) protein is present in considerable numbers of peripheral blood mononuclear cells (PBMCs) from viremic HIV-infected patients not on antiretroviral therapy (ART) and also in patients receiving virologically suppressive ART, though to a smaller degree. Interestingly, these Nef-positive PBMCs constitute predominantly uninfected bystander cells. These results may explain systemic pathology in HIV patients, even in those receiving ART.en_US
dc.identifier.citationWang, T., Green, L. A., Gupta, S. K., Amet, T., Byrd, D. J., Yu, Q., … Clauss, M. (2014). Intracellular Nef Detected in Peripheral Blood Mononuclear Cells from HIV Patients. AIDS Research and Human Retroviruses, 31(2), 217–220. http://doi.org/10.1089/aid.2013.0250en_US
dc.identifier.urihttps://hdl.handle.net/1805/9158
dc.language.isoen_USen_US
dc.publisherMary Ann Liebert, Inc.en_US
dc.relation.isversionof10.1089/aid.2013.0250en_US
dc.relation.journalAIDS Research and Human Retrovirusesen_US
dc.rightsPublisher Policyen_US
dc.sourcePMCen_US
dc.subjectBlooden_US
dc.subjectVirologyen_US
dc.subjectHIV Infectionsen_US
dc.subjectLeukocytes, Mononuclearen_US
dc.titleIntracellular Nef Detected in Peripheral Blood Mononuclear Cells from HIV Patientsen_US
dc.typeArticleen_US
ul.alternative.fulltexthttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4313413/en_US
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