Viscoelastic Hemostatic Assays: A Primer on Legacy and New Generation Devices

dc.contributor.authorVolod, Oksana
dc.contributor.authorBunch, Connor M.
dc.contributor.authorZackariya, Nuha
dc.contributor.authorMoore, Ernest E.
dc.contributor.authorMoore, Hunter B.
dc.contributor.authorKwaan, Hau C.
dc.contributor.authorNeal, Matthew D.
dc.contributor.authorAl-Fadhl, Mahmoud D.
dc.contributor.authorPatel, Shivani S.
dc.contributor.authorWiarda, Grant
dc.contributor.authorAl-Fadhl, Hamid D.
dc.contributor.authorMcCoy, Max L.
dc.contributor.authorThomas, Anthony V.
dc.contributor.authorThomas, Scott G.
dc.contributor.authorGillespie, Laura
dc.contributor.authorKhan, Rashid Z.
dc.contributor.authorZamlut, Mahmud
dc.contributor.authorKamphues, Peter
dc.contributor.authorFries, Dietmar
dc.contributor.authorWalsh, Mark M.
dc.contributor.departmentMedicine, School of Medicineen_US
dc.date.accessioned2023-05-12T14:22:03Z
dc.date.available2023-05-12T14:22:03Z
dc.date.issued2022-02-07
dc.description.abstractViscoelastic hemostatic assay (VHAs) are whole blood point-of-care tests that have become an essential method for assaying hemostatic competence in liver transplantation, cardiac surgery, and most recently, trauma surgery involving hemorrhagic shock. It has taken more than three-quarters of a century of research and clinical application for this technology to become mainstream in these three clinical areas. Within the last decade, the cup and pin legacy devices, such as thromboelastography (TEG® 5000) and rotational thromboelastometry (ROTEM® delta), have been supplanted not only by cartridge systems (TEG® 6S and ROTEM® sigma), but also by more portable point-of-care bedside testing iterations of these legacy devices (e.g., Sonoclot®, Quantra®, and ClotPro®). Here, the legacy and new generation VHAs are compared on the basis of their unique hemostatic parameters that define contributions of coagulation factors, fibrinogen/fibrin, platelets, and clot lysis as related to the lifespan of a clot. In conclusion, we offer a brief discussion on the meteoric adoption of VHAs across the medical and surgical specialties to address COVID-19-associated coagulopathy.en_US
dc.eprint.versionFinal published versionen_US
dc.identifier.citationVolod O, Bunch CM, Zackariya N, et al. Viscoelastic Hemostatic Assays: A Primer on Legacy and New Generation Devices. J Clin Med. 2022;11(3):860. Published 2022 Feb 7. doi:10.3390/jcm11030860en_US
dc.identifier.urihttps://hdl.handle.net/1805/32947
dc.language.isoen_USen_US
dc.publisherMDPIen_US
dc.relation.isversionof10.3390/jcm11030860en_US
dc.relation.journalJournal of Clinical Medicineen_US
dc.rightsAttribution 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.sourcePMCen_US
dc.subjectThromboelastographyen_US
dc.subjectRotational thromboelastometryen_US
dc.subjectCOVID-19en_US
dc.subjectCoagulopathyen_US
dc.subjectHemorrhageen_US
dc.subjectThrombosisen_US
dc.subjectPersonalized medicineen_US
dc.subjectFibrinogenen_US
dc.subjectHeparinen_US
dc.titleViscoelastic Hemostatic Assays: A Primer on Legacy and New Generation Devicesen_US
dc.typeArticleen_US
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