Kidney Histopathology and Prediction of Kidney Failure: A Retrospective Cohort Study

dc.contributor.authorEadon, Michael T.
dc.contributor.authorSchwantes-An, Tae-Hwi
dc.contributor.authorPhillips, Carrie L.
dc.contributor.authorRoberts, Anna R.
dc.contributor.authorGreene, Colin V.
dc.contributor.authorHallab, Ayman
dc.contributor.authorHart, Kyle J.
dc.contributor.authorLipp, Sarah N.
dc.contributor.authorPerez-Ledezma, Claudio
dc.contributor.authorOmar, Khawaja O.
dc.contributor.authorKelly, Katherine J.
dc.contributor.authorMoe, Sharon M.
dc.contributor.authorDagher, Pierre C.
dc.contributor.authorEl-Achkar, Tarek M.
dc.contributor.authorMoorthi, Ranjani N.
dc.contributor.departmentMedical and Molecular Genetics, School of Medicineen_US
dc.date.accessioned2023-03-09T11:20:39Z
dc.date.available2023-03-09T11:20:39Z
dc.date.issued2020-09
dc.description.abstractRationale & objective: The use of kidney histopathology for predicting kidney failure is not established. We hypothesized that the use of histopathologic features of kidney biopsy specimens would improve prediction of clinical outcomes made using demographic and clinical variables alone. Study design: Retrospective cohort study and development of a clinical prediction model. Setting & participants: All 2,720 individuals from the Biopsy Biobank Cohort of Indiana who underwent kidney biopsy between 2002 and 2015 and had at least 2 years of follow-up. New predictors & established predictors: Demographic variables, comorbid conditions, baseline clinical characteristics, and histopathologic features. Outcomes: Time to kidney failure, defined as sustained estimated glomerular filtration rate ≤ 10mL/min/1.73m2. Analytical approach: Multivariable Cox regression model with internal validation by bootstrapping. Models including clinical and demographic variables were fit with the addition of histopathologic features. To assess the impact of adding a histopathology variable, the amount of variance explained (r2) and the C index were calculated. The impact on prediction was assessed by calculating the net reclassification index for each histopathologic variable and for all combined. Results: Median follow-up was 3.1 years. Within 5 years of biopsy, 411 (15.1%) patients developed kidney failure. Multivariable analyses including demographic and clinical variables revealed that severe glomerular obsolescence (adjusted HR, 2.03; 95% CI, 1.51-2.03), severe interstitial fibrosis and tubular atrophy (adjusted HR, 1.99; 95% CI, 1.52-2.59), and severe arteriolar hyalinosis (adjusted HR, 1.53; 95% CI, 1.14-2.05) were independently associated with the primary outcome. The addition of all histopathologic variables to the clinical model yielded a net reclassification index for kidney failure of 5.1% (P < 0.001) with a full model C statistic of 0.915. Analyses addressing the competing risk for death, optimism, or shrinkage did not significantly change the results. Limitations: Selection bias from the use of clinically indicated biopsies and exclusion of patients with less than 2 years of follow-up, as well as reliance on surrogate indicators of kidney failure onset. Conclusions: A model incorporating histopathologic features from kidney biopsy specimens improved prediction of kidney failure and may be valuable clinically. Future studies will be needed to understand whether even more detailed characterization of kidney tissue may further improve prognostication about the future trajectory of estimated glomerular filtration rate.en_US
dc.eprint.versionAuthor's manuscripten_US
dc.identifier.citationEadon MT, Schwantes-An TH, Phillips CL, et al. Kidney Histopathology and Prediction of Kidney Failure: A Retrospective Cohort Study. Am J Kidney Dis. 2020;76(3):350-360. doi:10.1053/j.ajkd.2019.12.014en_US
dc.identifier.urihttps://hdl.handle.net/1805/31742
dc.language.isoen_USen_US
dc.publisherElsevieren_US
dc.relation.isversionof10.1053/j.ajkd.2019.12.014en_US
dc.relation.journalAmerican Journal of Kidney Diseasesen_US
dc.rightsPublisher Policyen_US
dc.sourcePMCen_US
dc.subjectKidney biopsyen_US
dc.subjectClinical prognosticationen_US
dc.subjectDisease progressionen_US
dc.subjecteGFR trajectoryen_US
dc.subjectEnd-stage renal disease (ESRD)en_US
dc.subjectEstimated glomerular filtration rate (eGFR)en_US
dc.subjectGlomerular obsolescenceen_US
dc.subjectHistopathologyen_US
dc.subjectInterstitial fibrosis and tubular atrophy (IFTA)en_US
dc.subjectPrognostic prediction modelen_US
dc.subjectRenal failureen_US
dc.titleKidney Histopathology and Prediction of Kidney Failure: A Retrospective Cohort Studyen_US
dc.typeArticleen_US
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