Signal Transduction during Metabolic and Inflammatory Reprogramming in Pulmonary Vascular Remodeling

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dc.contributor.authorGomes, Marta T.
dc.contributor.authorBai, Yang
dc.contributor.authorPotje, Simone R.
dc.contributor.authorZhang, Lu
dc.contributor.authorLockett, Angelia D.
dc.contributor.authorMachado, Roberto F.
dc.contributor.departmentMedicine, School of Medicineen_US
dc.date.accessioned2023-05-23T15:03:08Z
dc.date.available2023-05-23T15:03:08Z
dc.date.issued2022-02-22
dc.description.abstractPulmonary arterial hypertension (PAH) is a progressive disease characterized by (mal)adaptive remodeling of the pulmonary vasculature, which is associated with inflammation, fibrosis, thrombosis, and neovascularization. Vascular remodeling in PAH is associated with cellular metabolic and inflammatory reprogramming that induce profound endothelial and smooth muscle cell phenotypic changes. Multiple signaling pathways and regulatory loops act on metabolic and inflammatory mediators which influence cellular behavior and trigger pulmonary vascular remodeling in vivo. This review discusses the role of bioenergetic and inflammatory impairments in PAH development.en_US
dc.eprint.versionFinal published versionen_US
dc.identifier.citationGomes MT, Bai Y, Potje SR, Zhang L, Lockett AD, Machado RF. Signal Transduction during Metabolic and Inflammatory Reprogramming in Pulmonary Vascular Remodeling. Int J Mol Sci. 2022;23(5):2410. Published 2022 Feb 22. doi:10.3390/ijms23052410en_US
dc.identifier.urihttps://hdl.handle.net/1805/33184
dc.language.isoen_USen_US
dc.publisherMDPIen_US
dc.relation.isversionof10.3390/ijms23052410en_US
dc.relation.journalInternational Journal of Molecular Sciencesen_US
dc.rightsAttribution 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.sourcePMCen_US
dc.subjectPulmonary arterial hypertensionen_US
dc.subjectVascular remodelingen_US
dc.subjectSignaling pathwaysen_US
dc.subjectMetabolismen_US
dc.subjectInflammationen_US
dc.titleSignal Transduction during Metabolic and Inflammatory Reprogramming in Pulmonary Vascular Remodelingen_US
dc.typeArticleen_US
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