The Hyperglycemia Stranglehold Stifles Cutaneous Epithelial‒Mesenchymal Plasticity and Functional Wound Closure

dc.contributor.authorSen, Chandan K.
dc.contributor.authorRoy, Sashwati
dc.contributor.departmentSurgery, School of Medicineen_US
dc.date.accessioned2023-07-10T10:39:02Z
dc.date.available2023-07-10T10:39:02Z
dc.date.issued2021
dc.description.abstractIterative cycles of epithelial-mesenchymal transition (EMT) and mesenchymal to epithelial transition (MET) are responsible for epithelial plasticity necessary to achieve functional wound closure. Restoration of barrier function of the repaired skin is a hallmark of functional wound closure. Both EMT and MET are subject to control by glycemic status. New work in this issue supports the notion that hyperglycemia blunts epithelial plasticity.en_US
dc.eprint.versionAuthor's manuscripten_US
dc.identifier.citationSen CK, Roy S. The Hyperglycemia Stranglehold Stifles Cutaneous Epithelial‒Mesenchymal Plasticity and Functional Wound Closure. J Invest Dermatol. 2021;141(6):1382-1385. doi:10.1016/j.jid.2020.11.021en_US
dc.identifier.urihttps://hdl.handle.net/1805/34251
dc.language.isoen_USen_US
dc.publisherElsevieren_US
dc.relation.isversionof10.1016/j.jid.2020.11.021en_US
dc.relation.journalJournal of Investigative Dermatologyen_US
dc.rightsPublisher Policyen_US
dc.sourcePMCen_US
dc.subjectEpithelial-mesenchymal transitionen_US
dc.subjectHyperglycemiaen_US
dc.subjectSkinen_US
dc.subjectStifleen_US
dc.titleThe Hyperglycemia Stranglehold Stifles Cutaneous Epithelial‒Mesenchymal Plasticity and Functional Wound Closureen_US
dc.typeArticleen_US
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