The Hyperglycemia Stranglehold Stifles Cutaneous Epithelial‒Mesenchymal Plasticity and Functional Wound Closure
| dc.contributor.author | Sen, Chandan K. | |
| dc.contributor.author | Roy, Sashwati | |
| dc.contributor.department | Surgery, School of Medicine | en_US |
| dc.date.accessioned | 2023-07-10T10:39:02Z | |
| dc.date.available | 2023-07-10T10:39:02Z | |
| dc.date.issued | 2021 | |
| dc.description.abstract | Iterative cycles of epithelial-mesenchymal transition (EMT) and mesenchymal to epithelial transition (MET) are responsible for epithelial plasticity necessary to achieve functional wound closure. Restoration of barrier function of the repaired skin is a hallmark of functional wound closure. Both EMT and MET are subject to control by glycemic status. New work in this issue supports the notion that hyperglycemia blunts epithelial plasticity. | en_US |
| dc.eprint.version | Author's manuscript | en_US |
| dc.identifier.citation | Sen CK, Roy S. The Hyperglycemia Stranglehold Stifles Cutaneous Epithelial‒Mesenchymal Plasticity and Functional Wound Closure. J Invest Dermatol. 2021;141(6):1382-1385. doi:10.1016/j.jid.2020.11.021 | en_US |
| dc.identifier.uri | https://hdl.handle.net/1805/34251 | |
| dc.language.iso | en_US | en_US |
| dc.publisher | Elsevier | en_US |
| dc.relation.isversionof | 10.1016/j.jid.2020.11.021 | en_US |
| dc.relation.journal | Journal of Investigative Dermatology | en_US |
| dc.rights | Publisher Policy | en_US |
| dc.source | PMC | en_US |
| dc.subject | Epithelial-mesenchymal transition | en_US |
| dc.subject | Hyperglycemia | en_US |
| dc.subject | Skin | en_US |
| dc.subject | Stifle | en_US |
| dc.title | The Hyperglycemia Stranglehold Stifles Cutaneous Epithelial‒Mesenchymal Plasticity and Functional Wound Closure | en_US |
| dc.type | Article | en_US |