Genome-wide meta-analysis identifies eight new susceptibility loci for cutaneous squamous cell carcinoma

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dc.contributor.authorSarin, Kavita Y.
dc.contributor.authorLin, Yuan
dc.contributor.authorDaneshjou, Roxana
dc.contributor.authorZiyatdinov, Andrey
dc.contributor.authorThorleifsson, Gudmar
dc.contributor.authorRubin, Adam
dc.contributor.authorPardo, Luba M.
dc.contributor.authorWu, Wenting
dc.contributor.authorKhavari, Paul A.
dc.contributor.authorUitterlinden, Andre
dc.contributor.authorNijsten, Tamar
dc.contributor.authorToland, Amanda E.
dc.contributor.authorOlafsson, Jon H.
dc.contributor.authorSigurgeirsson, Bardur
dc.contributor.authorThorisdottir, Kristin
dc.contributor.authorJorgensen, Eric
dc.contributor.authorWhittemore, Alice S.
dc.contributor.authorKraft, Peter
dc.contributor.authorStacey, Simon N.
dc.contributor.authorStefansson, Kari
dc.contributor.authorAsgari, Maryam M.
dc.contributor.authorHan, Jiali
dc.contributor.departmentEpidemiology, School of Public Healthen_US
dc.date.accessioned2020-04-01T14:08:29Z
dc.date.available2020-04-01T14:08:29Z
dc.date.issued2020-02-10
dc.description.abstractCutaneous squamous cell carcinoma (SCC) is one of the most common cancers in the United States. Previous genome-wide association studies (GWAS) have identified 14 single nucleotide polymorphisms (SNPs) associated with cutaneous SCC. Here, we report the largest cutaneous SCC meta-analysis to date, representing six international cohorts and totaling 19,149 SCC cases and 680,049 controls. We discover eight novel loci associated with SCC, confirm all previously associated loci, and perform fine mapping of causal variants. The novel SNPs occur within skin-specific regulatory elements and implicate loci involved in cancer development, immune regulation, and keratinocyte differentiation in SCC susceptibility.en_US
dc.eprint.versionFinal published versionen_US
dc.identifier.citationSarin, K. Y., Lin, Y., Daneshjou, R., Ziyatdinov, A., Thorleifsson, G., Rubin, A., Pardo, L. M., Wu, W., Khavari, P. A., Uitterlinden, A., Nijsten, T., Toland, A. E., Olafsson, J. H., Sigurgeirsson, B., Thorisdottir, K., Jorgensen, E., Whittemore, A. S., Kraft, P., Stacey, S. N., Stefansson, K., … Han, J. (2020). Genome-wide meta-analysis identifies eight new susceptibility loci for cutaneous squamous cell carcinoma. Nature communications, 11(1), 820. https://doi.org/10.1038/s41467-020-14594-5en_US
dc.identifier.urihttps://hdl.handle.net/1805/22457
dc.language.isoen_USen_US
dc.publisherNature Researchen_US
dc.relation.isversionof10.1038/s41467-020-14594-5en_US
dc.relation.journalNature Communicationsen_US
dc.rightsAttribution 4.0 International*
dc.rights.urihttps://creativecommons.org/licenses/by/4.0*
dc.sourcePMCen_US
dc.subjectCancer geneticsen_US
dc.subjectGenome-wide association studiesen_US
dc.titleGenome-wide meta-analysis identifies eight new susceptibility loci for cutaneous squamous cell carcinomaen_US
dc.typeArticleen_US
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