Longitudinal diffusion changes in prodromal and early HD: Evidence of white-matter tract deterioration
dc.contributor.author | Shaffer, Joseph J. | |
dc.contributor.author | Ghayoor, Ali | |
dc.contributor.author | Long, Jeffrey D. | |
dc.contributor.author | Kim, Regina Eun-Young | |
dc.contributor.author | Lourens, Spencer | |
dc.contributor.author | O’Donnell, Lauren J. | |
dc.contributor.author | Westin, Carl-Fredrik | |
dc.contributor.author | Rathi, Yogesh | |
dc.contributor.author | Magnotta, Vincent | |
dc.contributor.author | Paulsen, Jane S. | |
dc.contributor.author | Johnson, Hans J. | |
dc.contributor.department | Biostatistics, School of Public Health | en_US |
dc.date.accessioned | 2020-02-06T15:14:26Z | |
dc.date.available | 2020-02-06T15:14:26Z | |
dc.date.issued | 2017-03 | |
dc.description.abstract | INTRODUCTION: Huntington's disease (HD) is a genetic neurodegenerative disorder that primarily affects striatal neurons. Striatal volume loss is present years before clinical diagnosis; however, white matter degradation may also occur prior to diagnosis. Diffusion-weighted imaging (DWI) can measure microstructural changes associated with degeneration that precede macrostructural changes. DWI derived measures enhance understanding of degeneration in prodromal HD (pre-HD). METHODS: As part of the PREDICT-HD study, N = 191 pre-HD individuals and 70 healthy controls underwent two or more (baseline and 1-5 year follow-up) DWI, with n = 649 total sessions. Images were processed using cutting-edge DWI analysis methods for large multicenter studies. Diffusion tensor imaging (DTI) metrics were computed in selected tracts connecting the primary motor, primary somato-sensory, and premotor areas of the cortex with the subcortical caudate and putamen. Pre-HD participants were divided into three CAG-Age Product (CAP) score groups reflecting clinical diagnosis probability (low, medium, or high probabilities). Baseline and longitudinal group differences were examined using linear mixed models. RESULTS: Cross-sectional and longitudinal differences in DTI measures were present in all three CAP groups compared with controls. The high CAP group was most affected. CONCLUSIONS: This is the largest longitudinal DWI study of pre-HD to date. Findings showed DTI differences, consistent with white matter degeneration, were present up to a decade before predicted HD diagnosis. Our findings indicate a unique role for disrupted connectivity between the premotor area and the putamen, which may be closely tied to the onset of motor symptoms in HD. Hum Brain Mapp 38:1460-1477, 2017. © 2017 Wiley Periodicals, Inc. | en_US |
dc.eprint.version | Author's manuscript | en_US |
dc.identifier.citation | Shaffer, J. J., Ghayoor, A., Long, J. D., Kim, R. E., Lourens, S., O'Donnell, L. J., … Johnson, H. J. (2017). Longitudinal diffusion changes in prodromal and early HD: Evidence of white-matter tract deterioration. Human brain mapping, 38(3), 1460–1477. doi:10.1002/hbm.23465 | en_US |
dc.identifier.uri | https://hdl.handle.net/1805/21996 | |
dc.language.iso | en_US | en_US |
dc.publisher | Wiley | en_US |
dc.relation.isversionof | 10.1002/hbm.23465 | en_US |
dc.relation.journal | Human Brain Mapping | en_US |
dc.rights | Publisher Policy | en_US |
dc.source | PMC | en_US |
dc.subject | Huntington disease | en_US |
dc.subject | Disease progression | en_US |
dc.subject | Prodromal | en_US |
dc.subject | White matter | en_US |
dc.subject | Diffusion tractography | en_US |
dc.subject | Diffusion magnetic resonance imaging | en_US |
dc.subject | Multicenter study | en_US |
dc.subject | Image processing | en_US |
dc.subject | Computer-assisted | en_US |
dc.title | Longitudinal diffusion changes in prodromal and early HD: Evidence of white-matter tract deterioration | en_US |
dc.type | Article | en_US |