Reducing cardiovascular risk through treatment of obstructive sleep apnea: 2 methodological approaches

dc.contributor.authorYaggi, Klar
dc.contributor.authorMittleman, Murray A.
dc.contributor.authorBravata, Dawn M.
dc.contributor.authorConcato, John
dc.contributor.authorWare, James
dc.contributor.authorStoney, Catherine M.
dc.contributor.authorRedline, Susan
dc.contributor.departmentDepartment of Medicine, IU School of Medicineen_US
dc.date.accessioned2017-06-19T20:17:58Z
dc.date.available2017-06-19T20:17:58Z
dc.date.issued2016-02
dc.description.abstractObstructive sleep apnea (OSA) significantly impacts cardiovascular health, demonstrated by observational investigations showing an independently increased risk of ischemic heart disease, diabetes, hypertension, congestive heart failure, acute coronary syndrome, stroke, cardiovascular mortality, and all-cause mortality. Positive airway pressure (PAP), a medical therapy for sleep apnea, reverses airway obstruction and may help reduce cardiovascular risk. Prior to planning large phase III randomized controlled trials to test the impact of PAP on cardiovascular outcomes, several gaps in knowledge need to be addressed. This article describes 2 independent studies that worked collaboratively to fill these gaps. The populations, design features, and relative benefits/challenges of the 2 studies (SleepTight and BestAIR) are described. Both studies were encouraged to have multidisciplinary teams with expertise in behavioral interventions to improve PAP compliance. Both studies provide key information that will be useful to the research community in future large-scale, event-driven, randomized trials to evaluate the efficacy and/or effectiveness of strategies to identify and treat significant OSA for decreasing risk of major adverse cardiovascular events in high-risk patients.en_US
dc.eprint.versionAuthor's manuscripten_US
dc.identifier.citationYaggi, K., Mittleman, M. A., Bravata, D. M., Concato, J., Ware, J., Stoney, C. M., & Redline, S. (2016). Reducing Cardiovascular Risk through Treatment of Obstructive Sleep Apnea: Two Methodological Approaches. American Heart Journal, 172, 135–143. http://doi.org/10.1016/j.ahj.2015.07.033en_US
dc.identifier.urihttps://hdl.handle.net/1805/13109
dc.language.isoen_USen_US
dc.publisherElsevieren_US
dc.relation.isversionof10.1016/j.ahj.2015.07.033en_US
dc.relation.journalAmerican Heart Journalen_US
dc.rightsPublisher Policyen_US
dc.sourcePMCen_US
dc.subjectSleep apnea syndromesen_US
dc.subjectCardiovascular diseasesen_US
dc.subjectPositive airway pressureen_US
dc.subjectStrokeen_US
dc.subjectTIAen_US
dc.titleReducing cardiovascular risk through treatment of obstructive sleep apnea: 2 methodological approachesen_US
dc.typeArticleen_US
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