Understanding Onset, Dynamic Transitions, and Associated Inequality Risk Factors for Adverse Posttraumatic Neuropsychiatric Sequelae After Trauma Exposure
dc.contributor.author | Lee, Chiyoung | |
dc.contributor.author | House, Stacey L. | |
dc.contributor.author | Beaudoin, Francesca L. | |
dc.contributor.author | Neylan, Thomas C. | |
dc.contributor.author | Clifford, Gari D. | |
dc.contributor.author | Linnstaedt, Sarah D. | |
dc.contributor.author | Germine, Laura T. | |
dc.contributor.author | Rauch, Scott L. | |
dc.contributor.author | Haran, John P. | |
dc.contributor.author | Storrow, Alan B. | |
dc.contributor.author | Lewandowski, Christopher | |
dc.contributor.author | Musey, Paul I., Jr. | |
dc.contributor.author | Hendry, Phyllis L. | |
dc.contributor.author | Sheikh, Sophia | |
dc.contributor.author | Punches, Brittany E. | |
dc.contributor.author | Swor, Robert A. | |
dc.contributor.author | Hudak, Lauren A. | |
dc.contributor.author | Pascual, Jose L. | |
dc.contributor.author | Seamon, Mark J. | |
dc.contributor.author | Harris, Erica | |
dc.contributor.author | Pearson, Claire | |
dc.contributor.author | Peak, David A. | |
dc.contributor.author | Domeier, Robert M. | |
dc.contributor.author | Rathlev, Niels K. | |
dc.contributor.author | O'Neil, Brian J. | |
dc.contributor.author | Sergot, Paulina | |
dc.contributor.author | Sanchez, Leon D. | |
dc.contributor.author | Bruce, Steven E. | |
dc.contributor.author | Sheridan, John F. | |
dc.contributor.author | Harte, Steven E. | |
dc.contributor.author | Koenen, Karestan C. | |
dc.contributor.author | Kessler, Ronald C. | |
dc.contributor.author | McLean, Samuel A. | |
dc.contributor.author | Yang, Qing | |
dc.contributor.author | An, Xinming | |
dc.contributor.department | Emergency Medicine, School of Medicine | |
dc.date.accessioned | 2025-05-16T11:44:16Z | |
dc.date.available | 2025-05-16T11:44:16Z | |
dc.date.issued | 2024-11-06 | |
dc.description.abstract | Objective: Several gaps remain in the understanding of the onset, dynamic transitions, and associated risk factors of adverse posttraumatic neuropsychiatric sequelae (APNS) in the acute post-trauma window. Based on serial assessments of symptoms from a large cohort study, we identified homogeneous statuses across multiple APNS symptom domains and investigated the dynamic transitions among these statuses during the first 2 months after trauma exposure. Furthermore, we studied how symptom onset and transitions are affected by equity-relevant characteristics. Methods: The analysis was based on 2557 participants enrolled in the Advancing Understanding of RecOvery afteR traumA (AURORA). APNS symptoms comprised pain, depression, sleep discontinuity, nightmares, avoidance, re-experience, anxiety, hyperarousal, somatic symptoms, and mental fatigue. We identified the homogeneous status of APNS symptoms at baseline, 1 month, and 2 months, and explored transition probabilities among these statuses using latent transition analysis. Equity-relevant characteristics included gender, race, education, family income, childhood trauma, and area deprivation. Results: Three homogeneous statuses-low-, moderate-, and severe-symptom-were identified. While the majority of trauma survivors with severe- or moderate-symptom status maintained the same status over time, some transitioned to a less severe symptom status, particularly within the first month. Specifically, females, non-whites, and those with higher childhood trauma were associated with a decreased likelihood of transitioning to a less severe symptom status. From one to 2 months, lower income was associated with a decreased likelihood of transitioning from moderate-to low-symptom status. Conclusions: The findings can inform early intervention strategies for APNS, potentially reducing health disparities among trauma survivors. | |
dc.eprint.version | Final published version | |
dc.identifier.citation | Lee C, House SL, Beaudoin FL, et al. Understanding Onset, Dynamic Transitions, and Associated Inequality Risk Factors for Adverse Posttraumatic Neuropsychiatric Sequelae After Trauma Exposure. Psychiatr Res Clin Pract. 2024;7(1):53-62. Published 2024 Nov 6. doi:10.1176/appi.prcp.20240017 | |
dc.identifier.uri | https://hdl.handle.net/1805/48191 | |
dc.language.iso | en_US | |
dc.publisher | American Psychiatric Association | |
dc.relation.isversionof | 10.1176/appi.prcp.20240017 | |
dc.relation.journal | Psychiatric Research and Clinical Practice | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 International | en |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | |
dc.source | PMC | |
dc.subject | Adverse posttraumatic neuropsychiatric sequelae (APNS) | |
dc.subject | Trauma exposure | |
dc.subject | Trauma survivors | |
dc.title | Understanding Onset, Dynamic Transitions, and Associated Inequality Risk Factors for Adverse Posttraumatic Neuropsychiatric Sequelae After Trauma Exposure | |
dc.type | Article |