Role of eIF2α Kinases in Translational Control and Adaptation to Cellular Stress

dc.contributor.authorWek, Ronald C.
dc.contributor.departmentBiochemistry and Molecular Biology, School of Medicineen_US
dc.date.accessioned2021-01-25T22:11:01Z
dc.date.available2021-01-25T22:11:01Z
dc.date.issued2018-12-12
dc.description.abstractA central mechanism regulating translation initiation in response to environmental stress involves phosphorylation of the α subunit of eukaryotic initiation factor 2 (eIF2α). Phosphorylation of eIF2α causes inhibition of global translation, which conserves energy and facilitates reprogramming of gene expression and signaling pathways that help to restore protein homeostasis. Coincident with repression of protein synthesis, many gene transcripts involved in the stress response are not affected or are even preferentially translated in response to increased eIF2α phosphorylation by mechanisms involving upstream open reading frames (uORFs). This review highlights the mechanisms regulating eIF2α kinases, the role that uORFs play in translational control, and the impact that alteration of eIF2α phosphorylation by gene mutations or small molecule inhibitors can have on health and disease.en_US
dc.identifier.citationWek, R. C. (2018). Role of eIF2α Kinases in Translational Control and Adaptation to Cellular Stress. Cold Spring Harbor Perspectives in Biology, 10(7), a032870. https://doi.org/10.1101/cshperspect.a032870en_US
dc.identifier.issn1943-0264en_US
dc.identifier.urihttps://hdl.handle.net/1805/24985
dc.language.isoen_USen_US
dc.publisherCold Spring Harbor Laboratory Pressen_US
dc.relation.isversionof10.1101/cshperspect.a032870en_US
dc.relation.journalCold Spring Harbor Perspectives in Biologyen_US
dc.sourcePMCen_US
dc.subjectProtein Biosynthesisen_US
dc.subjectPhysiological stressen_US
dc.subjectPhysiological adaptationen_US
dc.subjectProtein-Serine-Threonine Kinasesen_US
dc.titleRole of eIF2α Kinases in Translational Control and Adaptation to Cellular Stressen_US
dc.typeArticleen_US
ul.alternative.fulltexthttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6028073/en_US
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