Tractography-Pathology Correlations in Traumatic Brain Injury: A TRACK-TBI Study

dc.contributor.authorNolan, Amber L.
dc.contributor.authorPetersen, Cathrine
dc.contributor.authorIacono, Diego
dc.contributor.authorMac Donald, Christine L.
dc.contributor.authorMukherjee, Pratik
dc.contributor.authorvan der Kouwe, Andre
dc.contributor.authorJain, Sonia
dc.contributor.authorStevens, Allison
dc.contributor.authorDiamond, Bram R.
dc.contributor.authorWang, Ruopeng
dc.contributor.authorMarkowitz, Amy J.
dc.contributor.authorFischl, Bruce
dc.contributor.authorPerl, Daniel P.
dc.contributor.authorManley, Geoffrey T.
dc.contributor.authorKeene, C. Dirk
dc.contributor.authorDiaz-Arrastia, Ramon
dc.contributor.authorEdlow, Brian L.
dc.contributor.authorTRACK-TBI Investigators
dc.contributor.departmentPsychiatry, School of Medicine
dc.date.accessioned2025-01-31T08:47:31Z
dc.date.available2025-01-31T08:47:31Z
dc.date.issued2021
dc.description.abstractDiffusion tractography magnetic resonance imaging (MRI) can infer changes in network connectivity in patients with traumatic brain injury (TBI), but the pathological substrates of disconnected tracts have not been well defined because of a lack of high-resolution imaging with histopathological validation. We developed an ex vivo MRI protocol to analyze tract terminations at 750-μm isotropic resolution, followed by histopathological evaluation of white matter pathology, and applied these methods to a 60-year-old man who died 26 days after TBI. Analysis of 74 cerebral hemispheric white matter regions revealed a heterogeneous distribution of tract disruptions. Associated histopathology identified variable white matter injury with patchy deposition of amyloid precursor protein (APP), loss of neurofilament-positive axonal processes, myelin dissolution, astrogliosis, microgliosis, and perivascular hemosiderin-laden macrophages. Multiple linear regression revealed that tract disruption strongly correlated with the density of APP-positive axonal swellings and neurofilament loss. Ex vivo diffusion MRI can detect tract disruptions in the human brain that reflect axonal injury.
dc.eprint.versionFinal published version
dc.identifier.citationNolan AL, Petersen C, Iacono D, et al. Tractography-Pathology Correlations in Traumatic Brain Injury: A TRACK-TBI Study. J Neurotrauma. 2021;38(12):1620-1631. doi:10.1089/neu.2020.7373
dc.identifier.urihttps://hdl.handle.net/1805/45614
dc.language.isoen_US
dc.publisherMary Ann Liebert
dc.relation.isversionof10.1089/neu.2020.7373
dc.relation.journalJournal of Neurotrauma
dc.rightsPublisher Policy
dc.sourcePMC
dc.subjectContusion
dc.subjectMRI
dc.subjectNeuropathology
dc.subjectTractography
dc.subjectTraumatic axonal injury
dc.subjectTraumatic brain injury
dc.titleTractography-Pathology Correlations in Traumatic Brain Injury: A TRACK-TBI Study
dc.typeArticle
ul.alternative.fulltexthttps://pmc.ncbi.nlm.nih.gov/articles/PMC8165468/
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